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SYSTEMATIC REVIEW article

Front. Pediatr.
Sec. Children and Health
Volume 12 - 2024 | doi: 10.3389/fped.2024.1501401

Efficacy and safety of hemoporfin photodynamic therapy in treating port-wine stains in Chinese children: A systematic review and meta-analysis

Provisionally accepted
Jing Xu Jing Xu *Hongxin Li Hongxin Li
  • Children's Hospital of Capital Institute of Pediatrics, Beijing, China

The final, formatted version of the article will be published soon.

    The purpose of this study is to explore the efficacy and safety of hematoporphyrin monomethyl ether mediated photodynamic therapy (HMME-PDT) in treating children with port-wine stains (PWS).Method: Literature related to the topic was searched in PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang, and China Science Technology Journal Database online databases. The quality of the literature was evaluated using the Effective Public Health Practice Project. The I 2 statistic was used to evaluate the consistency of the results.Results: A total of 19 papers were included. Meta-analysis showed that more than half of the children (56.3%) achieved efficacy I (improvement ≥ 60%). 17% of children achieved efficacy II (improvement ≥ 75%). Regardless of whether the outcome variable was efficacy I or efficacy II, the therapeutic efficacy in children with PWS aged 0-3 years was superior to those aged 3-6 and 6-18 years, and children who underwent a treatment course of ≥ 3 sessions showed better outcomes compared to those who have only 1 or 2 sessions. After treatment with HMME-PDT, better efficacy was seen in the PWS of the face and neck and pink/red PWS. Additionally, almost all children with PWS treated with HMME-PDT developed edema (99.9%), more than half presented purpura (67.6%), some developed crust (30.8%) and hyperpigmentation (15.0%), and a few occurred scar (2.4%) and hypopigmentation (1.4%).After HMME-PDT treatment, more than half of the pediatric patients showed an improvement of ≥ 60%, and no serious adverse reaction events occurred.This study demonstrated that HMME-PDT possessed promising therapeutic efficacy in children with PWS, suggesting that HMME-PDT could be considered a recommended HMME-PDT in treating PWS in Chinese children treatment strategy for pediatric PWS. However, future development of standardized assessment guidelines and comparative studies are needed to validate the aforementioned conclusions. HMME-PDT in treating PWS in Chinese children

    Keywords: Port-wine stains, Hematoporphyrin monomethyl ether, Photodynamic therapy, Children, Meta-analysis

    Received: 25 Sep 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Xu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jing Xu, Children's Hospital of Capital Institute of Pediatrics, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.