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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Hematology and Hematological Malignancies
Volume 12 - 2024 | doi: 10.3389/fped.2024.1497943

A case of infantile acute hyperleukocytic leukemia treated by leukapheresis

Provisionally accepted
Shuang Bian Shuang Bian Nannan Li Nannan Li Hui Gao Hui Gao *
  • Dalian Women and Children’s Medical Center(Group), Dalian, China

The final, formatted version of the article will be published soon.

    Leukapheresis is a treatment used to reduce leukocytes to decrease the number of white blood cells in circulation and prevent the risks of hyperviscosity, cerebrovascular, and pulmonary leukostasis. We present a case of pro-B cell acute lymphoblastic leukemia with hyperleukocytosis in a six-month-old infant, characterized by a positive KMT2A/AFF1 fusion gene with a leukocyte count of 1755×10 9 /L. After two consecutive sessions of leukapheresis, the white blood cell count decreased to 55×10 9 /L. The infant recovered after the high-dose methotrexate chemotherapy. These results demonstrate that leukapheresis is a feasible treatment option for acute hyperleukocytic leukemia in infants with ALL.

    Keywords: Leukapheresis, Acute hyperleukocytic leukemia, Infant, Acute Lymphoblastic Leukemia, white blood cells

    Received: 18 Sep 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Bian, Li and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hui Gao, Dalian Women and Children’s Medical Center(Group), Dalian, China

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