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REVIEW article

Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1493540

Pediatric Pulmonary Function following Hematopoietic Stem Cell Transplantation: an update on Outcomes and Challenges

Provisionally accepted
Xiaowei Zhao Xiaowei Zhao 1,2Yuqi Zhao Yuqi Zhao 2Hongjuan Li Hongjuan Li 2Yan Gu Yan Gu 2Yanli Leng Yanli Leng 1,2Hongmei Wang Hongmei Wang 2Paulo Moreira Paulo Moreira 3,4,5*
  • 1 Jining Medical University, Jining, Shandong, China, Jining, China
  • 2 Department of Pediatrics, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China
  • 3 International Healthcare Management Research and Development Center (IHM-RDC), The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China, Jinan, China
  • 4 Henan Normal University, School of Social Affairs, Henan, China, Xinxiang, Henan Province, China
  • 5 Atlantica Instituto Universitario, Gestao em Saude, Oeiras, Portugal

The final, formatted version of the article will be published soon.

    Hematopoietic Stem Cell Transplantation (HSCT) is increasingly utilized for treating a variety of disorders, including malignancies and non-malignant conditions. Despite advancements leading to improved survival rates, pulmonary complications continue to be a major concern in the post-HSCT period, especially in pediatric patients. Pulmonary Function Tests (PFTs) are crucial for early detection and management of these complications, yet there is a lack of standardization in PFT surveillance and inconsistency in research findings.The article presents a comprehensive review of published evidence on the role of PFTs in pediatric HSCT recipients, focusing on their use in detecting pre-symptomatic pulmonary dysfunction and monitoring lung health over time. It identifies and discusses current research on post-transplant lung function trends, particularly in the pediatric cohort, and assesses various factors influencing pulmonary outcomes. The study also reviews the development of novel diagnostic tests for pulmonary complications post-HSCT.

    Keywords: search terms: "Hematopoietic stem cell transplantation", "pulmonary function testing， PFT"，"lung function", "Pulmonary function", "pediatrics", "Pulmonary chronic graft-versushost disease", "Pulmonary complications" in various combinations. The search all articles Hematopoietic Stem Cell Transplantation (HSCT)；Pediatric Pulmonary Function； Pulmonary Function Tests (PFTs)；Post-Transplant Complications；Lung Health Monitoring

    Received: 09 Sep 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Zhao, Zhao, Li, Gu, Leng, Wang and Moreira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Paulo Moreira, International Healthcare Management Research and Development Center (IHM-RDC), The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China, Jinan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.