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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Children and Health
Volume 12 - 2024 | doi: 10.3389/fped.2024.1488522
This article is part of the Research Topic Novel Approaches to Diet, Exercise, and Drugs in Childhood Obesity and Metabolic Diseases View all 3 articles

Changes of blood glucose and lipid metabolism levels in children with central precocious puberty and the correlation with obesity

Provisionally accepted
Xin Cui Xin Cui 1Xin Sun Xin Sun 2Qiubo Li Qiubo Li 3Zongbo Chen Zongbo Chen 1*
  • 1 The Affiliated Hospital of Qingdao University, Qingdao, China
  • 2 Integrative Medical Hospital of Jining City, Jining, China
  • 3 The Affiliated Hospital of Jining Medical University, Jining, China

The final, formatted version of the article will be published soon.

    Objective: This study focused on analyzing changes of blood glucose and lipid metabolism levels in children with central precocious puberty (CPP) and the correlation of CPP with obesity.: Eighty-eight CPP children aged 6-10 years admitted to our hospital from January 2023 to June 2024 (the CPP group) and eighty-eight non-CPP children of the same age group received health check-up (the Non-CPP group) were retrospectively collected. The general data [gender, age, bone age, and body mass index (BMI)] were collected. The levels of blood glucose metabolism indicators [fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), and hemoglobin A1c (HbA1c)], and blood lipid metabolism indicators [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] were compared. The incidence of obesity was counted, and the Tanner staging of the obese group and the non-obese group was compared. The correlation between CPP degree (Tanner staging) and obesity degree (BMI) was analyzed by Spearman correlation analysis.Results: The differences in gender and age between the CPP and Non-CPP groups were insignificant (P > 0.05); bone age and BMI of the CPP group were higher versus those of the Non-CPP group (P < 0.05). The CPP group possessed higher serum FPG, 2hPG, HbA1c, TG, TC, and LDL-C levels, and lower serum HDL-C levels versus the Non-CPP group. The incidence of obesity was raised in the CPP group 21.59% (19/88) versus in the Non-CPP group 6.82% (6/88).Tanner staging scores in the obese group for boys (testes and pubic hair), girls (breasts and pubic hair) and whole (testes/breasts and pubic hair) were elevated versus those in the non-obese group (P < 0.05). Spearman correlation displayed that the CPP degree (Tanner staging) was positively correlated with the obesity degree (BMI) in boys, girls and whole (P < 0.001).Children with CPP had abnormal levels of blood glucose and lipid metabolism, and the CPP degree in children was positively correlated with the degree of obesity.

    Keywords: precocious puberty, Blood Glucose, Blood lipids, Obesity, Correlation

    Received: 30 Aug 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Cui, Sun, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zongbo Chen, The Affiliated Hospital of Qingdao University, Qingdao, China

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