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CASE REPORT article

Front. Pediatr.
Sec. Neonatology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1477378

Hypercalcemia, subcutaneous fat necrosis and nephrocalcinosis in neonates who undergo therapeutic hypothermia: a not so rare association, with different onset time

Provisionally accepted
Domenico Umberto De Rose Domenico Umberto De Rose 1*Chiara Maddaloni Chiara Maddaloni 1Guglielmo Salvatori Guglielmo Salvatori 1Francesca Campi Francesca Campi 1Antonio Gatto Antonio Gatto 2Ludovica Martini Ludovica Martini 1Immacolata Savarese Immacolata Savarese 1Iliana Bersani Iliana Bersani 1Graziamaria Ubertini Graziamaria Ubertini 1Francesca Serrao Francesca Serrao 2Simonetta Costa Simonetta Costa 2Annabella Braguglia Annabella Braguglia 1Francesca Gallini Francesca Gallini 3Giovanni Vento Giovanni Vento 2ANDREA DOTTA ANDREA DOTTA 1
  • 1 Bambino Gesù Children's Hospital (IRCCS), Rome, Italy
  • 2 Agostino Gemelli University Polyclinic (IRCCS), Rome, Lazio, Italy
  • 3 Catholic University of the Sacred Heart, Rome, Rome, Sicily, Italy

The final, formatted version of the article will be published soon.

    Subcutaneous fat necrosis (SCFN) in newborns is an uncommon and self-limiting noninfectious panniculitis. It can occur in the first weeks of life in full-term newborns with hypoxicischemic encephalopathy who underwent therapeutic hypothermia. Hypercalcemia may develop and has been implicated as the cause of several complications as nephrocalcinosis. Hypercalcemia has been previously reported to appear only after resolution of skin lesions.Herein, we report how hypercalcemia can be evident already at diagnosis of subcutaneous fat necrosis after therapeutic hypothermia and can be associated with an early onset developing nephrocalcinosis.We compare two cases of these uncommon findings and review the recent literature.

    Keywords: Hypercalcemia, Therapeutic hypothermia, Nephrocalcinosis, neonate, hypoxic-ischemic encephalopathy, critical care medicine

    Received: 07 Aug 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 De Rose, Maddaloni, Salvatori, Campi, Gatto, Martini, Savarese, Bersani, Ubertini, Serrao, Costa, Braguglia, Gallini, Vento and DOTTA. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Domenico Umberto De Rose, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy

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