AUTHOR=Golshan-Tafti Mohammad , Bahrami Reza , Dastgheib Seyed Alireza , Hosein Lookzadeh Mohamad , Mirjalili Seyed Reza , Yeganegi Maryam , Aghasipour Maryam , Shiri Amirmasoud , Masoudi Ali , Shahbazi Amirhossein , Azizi Sepideh , Noorishadkam Mahmood , Neamatzadeh Hossein 

TITLE=The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1476180

DOI=10.3389/fped.2024.1476180

ISSN=2296-2360

ABSTRACT=Objective: Previous studies on the link between VEGF gene polymorphisms and bronchopulmonary dysplasia (BPD) have yielded inconsistent results. This meta-analysis sought to clarify the relationship between genetic variations in the VEGF gene and the risk of BPD.
Methods: Data were collected from multiple databases, including PubMed, Scopus, EMBASE, and CNKI, up to January 5, 2024.
Results: Nineteen case-control studies were analyzed, featuring 1,051 BPD cases and 1,726 healthy neonates. The analysis included four studies on the -460T/C polymorphism (312 cases, 536 controls), four on the -2578C/A polymorphism (155 cases, 279 controls), six on the +405G/C polymorphism (329 cases, 385 controls), and five on the +936C/T polymorphism (225 cases, 526 controls). The meta-analysis suggests that the -460T/C polymorphism may protect against BPD (C vs. T: OR=0.715, 95% CI 0.543-0.941, p=0.017; CC vs. TT: OR=0.478, 95% CI 0.233-0.983, p=0.045; CC vs. CT+TT: OR=0.435, 95% CI 0.248-0.764, p=0.004). No significant associations were found between the -2578C/A, +405G/C, and +936C/T polymorphisms and BPD susceptibility.
Conclusions: This meta-analysis indicates that the C allele of the -460T/C polymorphism may offer protection against BPD. No significant associations were observed for the -2578C/A, +405G/C, and +936C/T polymorphisms.