AUTHOR=Golshan-Tafti Mohammad , Bahrami Reza , Dastgheib Seyed Alireza , Hosein Lookzadeh Mohamad , Mirjalili Seyed Reza , Yeganegi Maryam , Aghasipour Maryam , Shiri Amirmasoud , Masoudi Ali , Shahbazi Amirhossein , Azizi Sepideh , Noorishadkam Mahmood , Neamatzadeh Hossein 

TITLE=The association between VEGF genetic variations and the risk of bronchopulmonary dysplasia in premature infants: a meta-analysis and systematic review

JOURNAL=Frontiers in Pediatrics

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1476180

DOI=10.3389/fped.2024.1476180

ISSN=2296-2360

ABSTRACT=<sec><title>Objective</title><p>Previous studies on the link between VEGF gene polymorphisms and bronchopulmonary dysplasia (BPD) have yielded inconsistent results. This meta-analysis sought to clarify the relationship between genetic variations in the VEGF gene and the risk of BPD.</p></sec><sec><title>Methods</title><p>Data were collected from multiple databases, including PubMed, Scopus, EMBASE, and CNKI, up to January 5, 2024.</p></sec><sec><title>Results</title><p>Nineteen case-control studies were analyzed, featuring 1,051 BPD cases and 1,726 healthy neonates. The analysis included four studies on the −460T/C polymorphism (312 cases, 536 controls), four on the −2578C/A polymorphism (155 cases, 279 controls), six on the +405G/C polymorphism (329 cases, 385 controls), and five on the +936C/T polymorphism (225 cases, 526 controls). The meta-analysis suggests that the −460T/C polymorphism may protect against BPD (C vs. T: OR =<sans-serif> 0</sans-serif>.715, 95% CI 0.543–0.941, <italic>p</italic> = 0.017; CC vs. TT: OR =<sans-serif> 0</sans-serif>.478, 95% CI 0.233–0.983, <italic>p</italic> = 0.045; CC vs. CT + TT: OR =<sans-serif> 0</sans-serif>.435, 95% CI 0.248–0.764, <italic>p</italic> = 0.004). No significant associations were found between the −2578C/A, +405G/C, and +936C/T polymorphisms and BPD susceptibility.</p></sec><sec><title>Conclusions</title><p>This meta-analysis indicates that the C allele of the −460T/C polymorphism may offer protection against BPD. No significant associations were observed for the −2578C/A, +405G/C, and +936C/T polymorphisms.</p></sec>