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CASE REPORT article

Front. Pediatr.
Sec. Neonatology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1464520

Transient hypothyroidism in a neonate following maternal exposure to vinblastine during pregnancy: A case report with review

Provisionally accepted
ZUBAIR AMIN ZUBAIR AMIN 1*Yvonne Peng Mei Ng Yvonne Peng Mei Ng 2Win Thu Aung Win Thu Aung 2
  • 1 Pediatrics, National University of Singapore, Singapore, Singapore
  • 2 National University of Singapore, Singapore, Singapore

The final, formatted version of the article will be published soon.

    Background: Vinblastine is a widely used chemotherapeutic agent for various cancers. We report a case of transient congenital hypothyroidism following maternal exposure to vinblastine during the 3 rd trimester of pregnancy and propose possible mechanisms of action.We utilized CARE Guideline in reporting the case.The mother is a 30-year-old previously healthy Malay lady who was diagnosed with Hodgkin lymphoma during her 28 th week of pregnancy. She received two cycles of vinblastine monotherapy in her third trimester. She delivered a healthy baby girl at 37 weeks of gestation. Cord blood screening for congenital hypothyroidism and subsequent thyroid function tests showed evidence of congenital hypothyroidism. The baby's ultrasound scan confirmed presence of the thyroid gland but there was no uptake of radionuclide tracer by the thyroid gland thereby excluding thyroid dysgenesis or dyshormonogenesis as a plausible cause of hypothyroidism. The baby was treated with replacement thyroxine for 18 months with eventual normal growth and development.This is the first report of transient congenital hypothyroidism following maternal exposure to vinblastine during the third trimester of pregnancy. Although direct causation cannot be established, a heightened awareness for neonatal hypothyroidism is recommended after exposure to vinblastine or similar drugs in pregnancy.

    Keywords: Vinca Alkaloids, Pregnancy, Toxicity, Vincristine, Fetus, neonate

    Received: 14 Jul 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 AMIN, Ng and Aung. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: ZUBAIR AMIN, Pediatrics, National University of Singapore, Singapore, Singapore

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