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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Endocrinology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1462406

Impact of Metabolic-associated fatty liver disease on the cholesterol efflux capacity of High-density lipoproteins in adolescents with type 2 diabetes

Provisionally accepted
Jose Antonio Orozco Morales Jose Antonio Orozco Morales 1,2AIDA MEDINA-URRUTIA AIDA MEDINA-URRUTIA 3Margarita Torres Tamayo Margarita Torres Tamayo 3*Juan Reyes Juan Reyes 3Esteban Jorge Galarza Esteban Jorge Galarza 3Juan G Juarez-Rojas Juan G Juarez-Rojas 3Pilar Dies Suarez Pilar Dies Suarez 4*NAHUM MENDEZ-SANCHEZ NAHUM MENDEZ-SANCHEZ 5,6Luis Enrique Díaz Orozco Luis Enrique Díaz Orozco 6*Lubia Velázquez López Lubia Velázquez López 7*Patricia Medina Bravo Patricia Medina Bravo 3,6*
  • 1 Department of Endocrinology, Hospital Infantil de México Federico Gómez, Mexico City, Mexico, Mexcico, Mexico
  • 2 Doctorate Program in Dental and Health Medical Sciences, National Autonomous University of Mexico, México, Mexico
  • 3 Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
  • 4 Federico Gómez Children's Hospital, Mexico City, México, Mexico
  • 5 Liver Research Unit, Fundación Clínica Médica Sur, Mexico City, Mexico, Mexico, Mexico
  • 6 National Autonomous University of Mexico, México City, México, Mexico
  • 7 General Regional Hospital No.1 Dr. Carlos Mac Gregor Sanchez Navarro, Mexican Social Security Institute (IMSS), Mexico City, México, Mexico

The final, formatted version of the article will be published soon.

    Context: Type 2 diabetes (DM2) is an emerging disease in the pediatric population. DM2 is associated with metabolic-associated fatty liver disease (MAFLD). High-density lipoproteins (HDLs) are lipoproteins that are believed to have atheroprotective properties that reduce the risk of cardiovascular disease (CVD). Current evidence suggests that the physicochemical and functional features of HDLs may play a key role in the pathogenesis of atherosclerosis.Objective: We aimed to assess the impact of MAFLD on cholesterol efflux capacity (CEC) in adolescents with DM2.

    Keywords: diabetes, MAFLD, adolescents, HDL, Cholesterol-efflux, Lipids

    Received: 10 Jul 2024; Accepted: 05 Nov 2024.

    Copyright: © 2024 Orozco Morales, MEDINA-URRUTIA, Tamayo, Reyes, Galarza, Juarez-Rojas, Dies Suarez, MENDEZ-SANCHEZ, Díaz Orozco, Velázquez López and Medina Bravo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Margarita Torres Tamayo, Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
    Pilar Dies Suarez, Federico Gómez Children's Hospital, Mexico City, 06720, México, Mexico
    Luis Enrique Díaz Orozco, National Autonomous University of Mexico, México City, 04510, México, Mexico
    Lubia Velázquez López, General Regional Hospital No.1 Dr. Carlos Mac Gregor Sanchez Navarro, Mexican Social Security Institute (IMSS), Mexico City, 3103, México, Mexico
    Patricia Medina Bravo, Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.