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REVIEW article

Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1456250
This article is part of the Research Topic Progress in clinical and mechanistic studies of severe respiratory viral infections in children View all articles

Current Antiviral Agents against Human Adenoviruses associated with Respiratory Infections

Provisionally accepted
Lexi Li Lexi Li Zhengde Xie Zhengde Xie Lili Xu Lili Xu *
  • Beijing Children’s Hospital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    Human adenoviruses (HAdVs) are important pathogens responsible for respiratory infections. In children and immunocompromised patients, respiratory infections can cause considerable morbidity and mortality. Currently, there are no approved effective and safe antiviral therapeutics for the clinical treatment of HAdV infections, even those that have undergone preclinical/clinical trials. However, many compounds and molecules with anti-HAdV activity have been explored, and some candidates are undergoing clinical development. Here, we reviewed the reported in vitro and in vivo efficacies, as well as the therapeutic potential of these antiviral compounds, providing an overview and a summary of the current status of anti-HAdV drug development.

    Keywords: Human adenovirus (HAdV), Antiviral Agents, respiratory infection, therapies, Nucleoside (acid) analogues

    Received: 28 Jun 2024; Accepted: 16 Aug 2024.

    Copyright: © 2024 Li, Xie and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lili Xu, Beijing Children’s Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.