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CASE REPORT article
Front. Pediatr.
Sec. Pediatric Immunology
Volume 12 - 2024 |
doi: 10.3389/fped.2024.1451472
Cronkhite-Canada Syndrome: Presentation of a Pediatric Case and Review of the Literature
Provisionally accepted- Hebei Provincial Children's Hospital, Shijiazhuang, China
Background: Cronkhite-Canada syndrome (CCS) is extremely rare in children, presenting with complex clinical manifestations often leading to misdiagnosis. Case presentation: We reported a description of a 13-year-old boy with CSS presenting with persistent diarrhea, vomiting, abdominal pain, along with symptoms of weight loss, alopecia, and skin hyperpigmentation. The patient had ectodermal manifestations such as alopecia and skin hyperpigmentation. Laboratory tests revealed hypoalbuminemia, normal inflammatory indicators, positive anti-dsDNA antibodies, anti-centromere antibodies, and anti-nuclear antibodies. Gastrointestinal endoscopy identified polypoid changes in the stomach, duodenum, and colon, with pathology indicating glandular dilation, cryptitis, and crypt abscesses. Treatment with prednisone led to significant improvement in symptoms, including normalization of stool consistency, hair regrowth, and disappearance of skin hyperpigmentation. Conclusion: This study emphasizes the importance of comprehensive assessment, endoscopic examination, histological biopsy, and the effectiveness of steroid therapy in the diagnosis and management of CCS in children. In children presenting with diarrhea, abdominal pain, weight loss, polyposis, and ectodermal manifestations, CCS should be considered.
Keywords: Cronkhite-Canada syndrome, Diarrhea, Gastrointestinal polyposis, Alopecia, Skin hyperpigmentation, Children
Received: 19 Jun 2024; Accepted: 05 Sep 2024.
Copyright: © 2024 Zhao, Fu, Zhao, Cheng, Hou and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ruiqin Zhao, Hebei Provincial Children's Hospital, Shijiazhuang, China
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