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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 12 - 2024 | doi: 10.3389/fped.2024.1450563

Ocular Paroxysmal Non-Epileptic Events as the Presenting Sign of Celiac Disease in Children: a case series

Provisionally accepted
Alice Monzani Alice Monzani 1*Giulia Genoni Giulia Genoni 2Amanda Papa Amanda Papa 2Noemi Paggi Noemi Paggi 1Eleonora Capra Eleonora Capra 1Francesca Brustia Francesca Brustia 2Ivana Rabbone Ivana Rabbone 1
  • 1 Scuola di Medicina, Università degli Studi del Piemonte Orientale, Novara, Italy
  • 2 Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Italy

The final, formatted version of the article will be published soon.

    Introduction: Neurologic manifestations may be presenting signs of celiac disease (CD). Pediatriconset paroxysmal non-epileptic events (PNEEs) are not included among them. Cases presentation: We report the case of two children who presented with ocular PNEEs in association with mild symptoms evocative for CD, who were subsequently diagnosed with CD and experienced regression of PNEEs on a gluten-free diet. Data from 12 patients undergoing neurological evaluation in 2019-2023 for ocular PNEEs were reviewed: 3 (25%) had a subsequent diagnosis of CD. Conclusions: Ocular PNEEs could be a presenting manifestation of CD. In the diagnostic work-up of PNEEs, screening for CD could be included, both to avoid unnecessary tests and to promptly start a gluten-free diet, which might lead to a favorable clinical response.

    Keywords: Celiac Disease, Children, pediatric, Eye Movements, Neurologic Manifestations, pediatriconset non-epileptic paroxysmal events

    Received: 17 Jun 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Monzani, Genoni, Papa, Paggi, Capra, Brustia and Rabbone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alice Monzani, Scuola di Medicina, Università degli Studi del Piemonte Orientale, Novara, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.