AUTHOR=Ozkan Zarif Nurten , Arayici Sema , Celik Kiymet , Kihtir Zeynep , Ongun Hakan 

TITLE=Intranasal dexmedetomidine reduces pain scores in preterm infants during retinopathy of prematurity screening

JOURNAL=Frontiers in Pediatrics

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1441324

DOI=10.3389/fped.2024.1441324

ISSN=2296-2360

ABSTRACT=<sec><title>Background</title><p>This study aimed to investigate the effectiveness of intranasal dexmedetomidine in reducing pain scores during retinopathy of prematurity (ROP) screening examinations in preterm infants.</p></sec><sec><title>Methods</title><p>Infants born at ≤32 weeks of gestational age, undergoing routine ROP examinations in the neonatal intensive care unit, were included in the study and divided into two groups: the standard protocol group (<italic>n</italic> = 43) and the dexmedetomidine group (<italic>n</italic> = 56), over a 1-year period. Both groups received standard procedural preparation including swaddling, oral dextrose, and topical anesthesia with proparacaine. The dexmedetomidine group additionally received intranasal dexmedetomidine at a dose of 1 mcg/kg before the procedure. Pain scores (PIPP score), heart rate, respiratory rate, blood pressure, and oxygen saturation were compared at baseline, 1-min, and 5-min during the procedure.</p></sec><sec><title>Results</title><p>There were no significant differences between the groups regarding descriptive and pre-procedure characteristics. In the dexmedetomidine group, the median (25-75p) PIPP score, heart rate, systolic blood pressure and mean (±SD) respiratory rate measured at the 1st minute of the procedure were significantly lower than those in the standard group [PIPP score 10 (8–13) vs. 14 (10–16), <italic>p</italic> &lt; 0.001; heart rate 165 (153–176) beats/min vs. 182 (17–190) beats/min, <italic>p</italic> &lt; 0.001; respiratory rate 60 (±7) breaths/min vs. 65(±9) breaths/min, <italic>p</italic> = 0.002; systolic blood pressure 78 (70–92) mmHg vs. 87 (78–96) mmHg, <italic>p</italic> = 0.024; respectively] whereas the saturation value was significantly higher (88% (81–95) vs. 84% (70–92), <italic>p</italic> = 0.036; respectively). By the 5th minute of the procedure, the median (25-75p) PIPP score [4 (2–6) vs. 6 (4–10), <italic>p</italic> &lt; 0.001], heart rate [148 (143–166) beats/min vs. 162 (152–180) beats/min, <italic>p</italic> = 0.001] and respiratory rate [56 (54–58) breaths/min vs. 58 (54–62) breaths/min, <italic>p</italic> = 0.034] were significantly lower, and the saturation level was significantly higher [96% (94–97) vs. 93% (91–96), <italic>p</italic> = 0.003] in the dexmedetomidine group. Additionally, the frequency of adverse effects was significantly lower in the dexmedetomidine group compared to the standard protocol group (11% vs. 47%, <italic>p</italic> = 0.001).</p></sec><sec><title>Conclusion</title><p>Administering intranasal dexmedetomidine before ROP screening examinations was associated with a decrease in pain scores among preterm infants. This suggests its potential as an effective and well-tolerated method for pain management during ROP screenings.</p></sec>