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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Neurology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1440190

Care mode on child with cerebral palsy Different care mode alter composition and function of gut microbiota in cerebral palsy children

Provisionally accepted
Huang Congfu Huang Congfu 1*Jinli Lyu Jinli Lyu 2Xiaowei Zhang Xiaowei Zhang 2Shenghua Xiong Shenghua Xiong 1Hui Wu Hui Wu 3Jing Han Jing Han 1Yongjie Xie Yongjie Xie 1Feifeng Qiu Feifeng Qiu 4
  • 1 Shenzhen Longgang District Maternal and Child Health Care Hospital, Shenzhen, China
  • 2 Shenzhen Hospital, Peking University, Shenzhen, Beijing Municipality, China
  • 3 The Second People’s Hospital of Panyu Guangzhou, Guangzhou, Guangdong Province, China
  • 4 Jinan University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Specialized care is essential for the recovery of children with cerebral palsy (CP). This study investigates how different care modes impact the gut microbiota. Fecal samples from 32 children were collected, among whom those cared for by family (n=21) were selected as the observation group, and those cared for by children's welfare institutions (n=11) were selected as the control group (registration number of LGFYYXLL-024).The gut microbiota profiles were analyzed. There was no significant difference in the α-diversity of the gut microbiota and the abundance at the phylum level. However, at the genus level, the observation group showed a significant increase in the abundance of butyrate-producing bacteria Bacteroides and Lachnospiracea incertae sedis (P<0.05), and a significant decrease in the abundance of opportunistic pathogens Prevotella, Clostridium cluster IV, Oscillibacter, and Fusobacterium (P<0.05).Additionally, lipid metabolism, carbohydrate metabolism, transcription, cellular processes and signaling, and membrane transport were significantly upregulated in the observation group. Lipid metabolism was positively correlated with Bacteroides and Lachnospiracea incertae sedis, indicating a positive impact of the family-centered care mode on bacterial metabolism processes. This study highlights that the family-centered care mode had a positive impact on the composition and function of the gut microbiota.The study provides valuable insights into the relationship between care mode and gut microbiota, which can inspire the development of interventions for cerebral palsy.

    Keywords: Cerebral Palsy, Gut micobiota, Family-centered care mode, Welfare-centered care mode, 16S rRNA sequence

    Received: 05 Jun 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Congfu, Lyu, Zhang, Xiong, Wu, Han, Xie and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huang Congfu, Shenzhen Longgang District Maternal and Child Health Care Hospital, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.