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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Neonatology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1439876
This article is part of the Research Topic What is new on the Horizon in Neonatology? Recent Advances in Monitoring, Diagnostics, and Therapeutics in Neonatal Care. View all 19 articles

Postnatal levels of glycated albumin and glycated hemoglobin A1c in mothers of large-for-gestational-age newborns

Provisionally accepted
Mojca Železnik Mojca Železnik 1*Alenka Trampuš Bakija Alenka Trampuš Bakija 2Darja Paro-Panjan Darja Paro-Panjan 1Aneta Soltirovska-Šalamon Aneta Soltirovska-Šalamon 1
  • 1 Department of Neonatology, Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia
  • 2 Department of Special Laboratory Diagnostics, University Children’s Hospital, University Medical Centre, Ljubljana, Slovenia

The final, formatted version of the article will be published soon.

    Background: Gestational diabetes mellitus (GDM) is an important cause of macrosomia. The value of glycated albumin (GlyA) has been demonstrated to be a useful marker of glycemic control in pregnancy and a predictor of adverse perinatal outcomes. The aim of this study was to investigate the relationship between the postnatal levels of GlyA and glycated hemoglobin A1c (HbA1c) regarding the prenatal diagnosis of GDM in mothers of large-for-gestational-age (LGA) newborns.The study included mothers and their LGA newborns born between July 2017 and September 2019. The mothers were grouped according to the prenatal diagnosis of GDM, and measurements of GlyA and HbA1c levels in their serum were performed on the first day after delivery of a LGA newborn.Results: A total of 61 LGA newborns and their mothers were enrolled in the study. The median GlyA level was higher, at 16.4% (81.0 µmol/L), whereas the HbA1c level was lower in the group without a prenatal diagnosis of GDM; the differences between groups regarding the GlyA and HbA1c levels were not significant (p > 0.05). The postnatal level of maternal GlyA was positively correlated with birth weight (β = 0.022, p = 0.007), but no correlation with the presence of other adverse perinatal outcomes was found.Mothers of LGA newborns who were not diagnosed with GDM during pregnancy had higher median levels of GlyA and lower HbA1c levels than mothers with prenatal diagnosis of GDM. Values of GlyA in mothers were positively correlated with the birth weight of their newborns but no correlation with other adverse perinatal outcomes was found. Our results indicate the potential value of GlyA for screening of GDM in the last trimester of pregnancy.

    Keywords: gestational diabetes mellitus, Glycated albumin, Glycated hemoglobin, large for gestational age, Newborn

    Received: 28 May 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Železnik, Trampuš Bakija, Paro-Panjan and Soltirovska-Šalamon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mojca Železnik, Department of Neonatology, Children’s Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia

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