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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Endocrinology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1438195

Causal Relationship between the Composition of the Gut Microbiota and Central Precocious Puberty: A Two-Sample Mendelian Randomization Study

Provisionally accepted
Minhong Chen Minhong Chen 1Xueqin Huang Xueqin Huang 1*Wanhong Huang Wanhong Huang 2*Chuangang Ding Chuangang Ding 3*
  • 1 Dali University, Dali, China
  • 2 Guangzhou Medical University, Guangzhou, Guangdong Province, China
  • 3 The First Affiliated Hospital of Dali University, Dali, Yunnan, China

The final, formatted version of the article will be published soon.

    Previous observational research has demonstrated a possible association between the gut microbiota (GM) and central precocious puberty (CPP). Nevertheless, whether there is a causal relationship between the GM and CPP is uncertain due to the possibility of confounding factors influencing the result.We collected summary data from genome-wide association studies of the GM (MiBioGen, n=18,340) and CPP (FinnGen Consortium, 185 case groups and 395,289 controls). Most of the participants were of European origin. Mendelian randomization analysis was utilized to investigate the causal relationship between the GM and CPP using the inverse-variance weighted average technique, the weighted median, and Mendelian randomization Egger. The reliability of the results was evaluated using the leave-one-out test and sensitivity analyses, including heterogeneity and horizontal pleiotropy testing.According to the inverse-variance weighted average technique, there was a substantial correlation between CPP and the composition of the GM. Specifically, the relative abundance of the genus Bacteroides (OR 0.222, 95% CI 0.06-0.822, P=0.024) and Alistipes (OR 0.197, 95% CI 0.056-0.697, P=0.012), and others, showed significant

    Keywords: Gut Microbiota, central precocious puberty, Mendelian randomization, causal relationship, Genetics

    Received: 25 May 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Chen, Huang, Huang and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xueqin Huang, Dali University, Dali, China
    Wanhong Huang, Guangzhou Medical University, Guangzhou, 510170, Guangdong Province, China
    Chuangang Ding, The First Affiliated Hospital of Dali University, Dali, Yunnan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.