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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Rheumatology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1433481

IVIG Causing Bilateral Papilledema and Increased Intracranial Hypertension in Patients with Anti-TIF-1 Antibody Positive JDM

Provisionally accepted
Sarah Baluta Sarah Baluta 1,2*Ivana Stojkic Ivana Stojkic 3Kyla Driest Kyla Driest 3Christina Schutt Christina Schutt 1,2
  • 1 University of Rochester Medical Center, Rochester, United States
  • 2 Golisano Children's Hospital, Rochester, New York, United States
  • 3 Nationwide Children's Hospital, Columbus, Ohio, United States

The final, formatted version of the article will be published soon.

    Juvenile dermatomyositis is a systemic autoimmune disease characterized by progressive proximal muscle weakness, pathognomonic rashes, and often myositis specific antibodies. Consensus treatment plans for pediatric patients with juvenile dermatomyositis recommend steroids and methotrexate as initial therapy. Patients with anti-TIF-gamma antibodies tend to have more refractory disease requiring more aggressive treatment with intravenous immunoglobulin that is typically well tolerated. We describe two pediatric patients diagnosed with anti-TIF-1-gamma antibody positive juvenile dermatomyositis who developed persistent increased intracranial pressure with intravenous immunoglobulin treatment. These cases suggest a potential association between treatment with intravenous immunoglobulin and increased intracranial pressure that is not a readily known side effect. The shared anti-TIF-1-gamma positivity in both patients may suggest a possible concern for intracranial hypertension among juvenile dermatomyositis patients with this myositis specific antibody.

    Keywords: Juvenile Dermatomyositis1, Anti-TIF-1 Antibody2, Intravenous Immunoglobulin3, Increased Intracranial Pressure4, Myositis specific antibodies

    Received: 15 May 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Baluta, Stojkic, Driest and Schutt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sarah Baluta, University of Rochester Medical Center, Rochester, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.