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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Critical Care
Volume 12 - 2024 | doi: 10.3389/fped.2024.1433417

Clinical Characteristics and Early Identification of Augmented Renal Clearance in PICU Patients with Severe Sepsis associated with MRSA infection

Provisionally accepted
Haonan Wang Haonan Wang 1Jiaqing Li Jiaqing Li 2Xian Li Xian Li 1Han Li Han Li 1Yinglang He Yinglang He 1Rui Tan Rui Tan 1Xuejian Mei Xuejian Mei 1Haoyu Zha Haoyu Zha 3Mingxing Fan Mingxing Fan 1Shuangshuang Peng Shuangshuang Peng 1Nan Hou Nan Hou 1Zhe Li Zhe Li 1Yue Wang Yue Wang 1Yao Liu Yao Liu 4Hongjun Miao Hongjun Miao 1*
  • 1 Department of Emergency Medicine and Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China
  • 2 Department of Anesthesiology, Nanjing Children's Hospital, Nanjing, Liaoning Province, China
  • 3 School of Pediatrics, Nanjing Medical University, Nanjing, Jiangsu Province, China
  • 4 Department of Pharmacy, Nanjing Children's Hospital, Nanjing, Liaoning Province, China

The final, formatted version of the article will be published soon.

    To investigate the epidemiological characteristics of Augmented Renal Clearance (ARC) in severe sepsis children with MRSA infection and find risk factors to establish a model predicting ARC onset in PICU.Retrospective study, in which ARC was defined by estimated glomerular filtration rate (eGFR) measured by the modified Schwartz formula above 130 mL/min/1.73m 2 . Univariable and multivariable logistic regression analyses were performed to find the predictor for ARC. Multistrategy modeling was used to form an early prediction model for ARC, which was evaluated by the area under the ROC curve (AUC), accuracy (ACC) and other indicators.One China PICU.

    Keywords: severe sepsis1, MRSA2, vancomycin3, augmented renal clearance4, prediction model5. 2

    Received: 15 May 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Wang, Li, Li, Li, He, Tan, Mei, Zha, Fan, Peng, Hou, Li, Wang, Liu and Miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongjun Miao, Department of Emergency Medicine and Pediatric Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.