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CASE REPORT article
Front. Pediatr.
Sec. Pediatric Rheumatology
Volume 12 - 2024 |
doi: 10.3389/fped.2024.1432362
Adolescent Takayasu's Arteritis with Hypertensive Intracerebral Hemorrhage: A Case Report and Literature Review
Provisionally accepted- 1 The Affiliated Hospital of Qingdao University, Qingdao, China
- 2 Tai'an City Central Hospital, Tai’an, Shandong, China
- 3 Graduate School of Jinzhou Medical University, Shenyang, Liaoning Province, China
- 4 Dandong First Hospital, Dandong, Liaoning Province, China
Takayasu's arteritis is a primary systemic vasculitis that affects predominantly large vessels, affecting the aorta and its major branches.. We report a case of adolescent female patient who initially experienced numbness and weakness in her limbs, subsequently developing severe hypertension. Physical examination revealed uneven blood pressure in the limbs and a murmur in the auscultation area of the abdominal aorta without decreased pulses. Auxiliary examinations revealed diffuse blood vessel stenosis, leading to the diagnosis of Takayasu's arteritis. One month later, the patient was diagnosed with multiple cerebral hemorrhages following sudden impairment of limb movement. Digital subtraction angiography did not reveal any evident vascular malformations or aneurysms. Following surgery and biologic intervention with tocilizumab the patient's condition improved, with no new bleeding episodes and stable blood pressure control achieved. We also reviewed the literature that have been previously reported with hypertensive intracerebral hemorrhage complicated by Takayasu's arteritis. We recommend that Takayasu's arteritis be taken into account when considering the hypertension in young patients. Timely vascular imaging and standardized treatment are imperative for diagnosing and managing effectively.
Keywords: Takayasu's arteritis, renal artery stenosis, Hypertension, Cerebral Hemorrhage, Adolescent
Received: 13 May 2024; Accepted: 01 Aug 2024.
Copyright: © 2024 Zhang, Dong, Yang, Liu, Zhan, Cui, Lin, Wang and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenshan Lv, The Affiliated Hospital of Qingdao University, Qingdao, China
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