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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Surgery
Volume 12 - 2024 | doi: 10.3389/fped.2024.1418616

Laparoscopic-assisted sclerotherapy in pediatric retroperitoneal lymphatic malformations

Provisionally accepted
Shi Hao Shi Hao Lv zhibao Lv zhibao Xu Weijue Xu Weijue Jiangbin Liu Jiangbin Liu Sheng Qingfeng Sheng Qingfeng Ren Xiang Ren Xiang Zhou Chen Zhou Chen *
  • Shanghai Children's Hospital, Shanghai, China

The final, formatted version of the article will be published soon.

    Background：Retroperitoneal Lymphatic malformations (LMs) are rare. Currently, the treatment of retroperitoneal LMs remains challenging.The purpose of this study was to examine safety and efficacy of laparoscopic-assisted sclerotherapy for retroperitoneal LMs in pediatric patients. Methods：We retrospectively reviewed the patients treated with laparoscopic-assisted sclerotherapy for retroperitoneal LMs in a single tertiary medical center between July 2020 and February 2023. Doxycycline was prepared into a solution with a concentration of 10 mg/ml for use in sclerotherapy. Demographic data, clinical features, details of management, and outcomes were collected and analyzed. Results：A total of six patients, comprising three males and three females, were identified. The LMs were categorized into four macrocystic and two mixed-cystic types. The mean age and weight were 52.2 months (range 11-108 months) and 20kg (range 12.5-27.5kg), respectively. Three patients presented with abdominal pain or distension, while the other three patients were asymptomatic. All six patients underwent a total of eight sclerotherapy sessions. Two patients experienced intra-cystic hemorrhage and required a second sclerotherapy session. Only one patient presented with vomiting after sclerotherapy, which resolved spontaneously. Five patients met the complete response criteria, and one patient met the effective criteria. The mean reduction in lesion size was 92.3% (range: 69.9%-99.6%). No further complications or recurrence were recorded during follow-up. Conclusion：Laparoscopic-assisted sclerotherapy is a safe and effective approach for treating retroperitoneal LMs. This technique is applicable for both macrocystic and mixed-cystic retroperitoneal LMs.

    Keywords: Laparoscopy, Lymphatic malformations, Sclerotherapy, Children, Retroperitoneal

    Received: 16 Apr 2024; Accepted: 19 Jun 2024.

    Copyright: © 2024 Hao, zhibao, Weijue, Liu, Qingfeng, Xiang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhou Chen, Shanghai Children's Hospital, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.