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REVIEW article

Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 12 - 2024 | doi: 10.3389/fped.2024.1417644

Research progress of biomarkers in evaluating the severity and prognostic value of severe pneumonia in children

Provisionally accepted
Weihua Gong Weihua Gong 1Kaijie Gao Kaijie Gao 1Zhiming Shan Zhiming Shan 1Liu Yang Liu Yang 1Panpan Fang Panpan Fang 1Ci Li Ci Li 1Junmei Yang Junmei Yang 1*Jiajia Ni Jiajia Ni 2*
  • 1 Children’s Hospital Affiliated of Zhengzhou University, Zhengzhou, China
  • 2 Guangzhou National Laboratory, Guangzhou, China

The final, formatted version of the article will be published soon.

    Pneumonia is a serious and common infectious disease in children. If not treated in time, it may develop into severe pneumonia. Severe pneumonia in children is mainly characterized by hypoxia and acidosis, often accompanied by various complications such as sepsis and multiple organ dysfunction. Severe pneumonia has a rapid onset and progression, and a high mortality rate. Biomarkers assist clinicians in the early diagnosis and treatment of patients by quickly and accurately identifying their conditions and prognostic risks. In this study, common clinical and novel biomarkers of severe pneumonia in children were reviewed, and the application value of biomarkers related to the severity and prognosis of severe pneumonia in children was evaluated to provide help for early identification and precise intervention by clinicians.

    Keywords: Severe pneumonia, Child, biomarkers, prognosis, severity

    Received: 17 Apr 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Gong, Gao, Shan, Yang, Fang, Li, Yang and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Junmei Yang, Children’s Hospital Affiliated of Zhengzhou University, Zhengzhou, China
    Jiajia Ni, Guangzhou National Laboratory, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.