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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 12 - 2024 | doi: 10.3389/fped.2024.1416189

Case report:Mycoplasma pneumoniae associated acute pancreatitis

Provisionally accepted
Hong Sun Hong Sun 1Wei-Qun Wang Wei-Qun Wang 1*Long Lin Long Lin 1*Zheng-Yang Shao Zheng-Yang Shao 1*Lu Zhan Lu Zhan 1*Lan-Fang Tang Lan-Fang Tang 2*
  • 1 Hangzhou Red Cross Hospital, Hangzhou, China
  • 2 Department of Pulmonology, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Mycoplasma pneumoniae is the primary pathogen causing community-acquired pneumonia in children, accounting for approximately 10% to 40%. It can lead to various extrapulmonary complications, including acute pancreatitis, which has been reported in about 30 cases till now. Here, we report a 4-year-old girl who presented with fever, cough, and elevated levels of Mycoplasma pneumoniae IgM antibodies, followed by the onset of abdominal pain, elevated lipase, and elevated blood and urine amylase. The abdominal CT implied diffuse inflammation of the pancreas.Serum inflammatory cytokines, such as IL-2, IL-6, IL-17A, TNF, and IFN-γ were elevated. After excluding other causes, it was determined that Mycoplasma pneumoniae infection was the cause of her acute pancreatitis. She was treated with macrolides and glucocorticoids and ultimately made a full recovery. Therefore, acute pancreatitis should be included in the differential diagnosis for patients with Mycoplasma pneumoniae infection who present with abdominal pain. Inflammatory cytokines may play a role in mediating pancreatic damage.

    Keywords: Mycoplasma pneumoniae, Extrapulmonary complications, acute pancreatitis, cytokine, Children

    Received: 12 Apr 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Sun, Wang, Lin, Shao, Zhan and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Wei-Qun Wang, Hangzhou Red Cross Hospital, Hangzhou, China
    Long Lin, Hangzhou Red Cross Hospital, Hangzhou, China
    Zheng-Yang Shao, Hangzhou Red Cross Hospital, Hangzhou, China
    Lu Zhan, Hangzhou Red Cross Hospital, Hangzhou, China
    Lan-Fang Tang, Department of Pulmonology, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, Jiangsu Province, China

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