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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. General Pediatrics and Pediatric Emergency Care
Volume 12 - 2024 | doi: 10.3389/fped.2024.1412729

Risk factors for pleural effusion in children with plastic bronchitis caused by pneumonia

Provisionally accepted
Xiaoliang Lin Xiaoliang Lin 1,2Enhui Xu Enhui Xu 1*Tan Zhang Tan Zhang 1*Qiguo Zhu Qiguo Zhu 1Deyi Zhuang Deyi Zhuang 1,2*
  • 1 Xiamen Children's Hospital, Xiamen, China
  • 2 Fujian Key Laboratory of Neonatal Diseases, Xiamen Children’s Hospital, Xiamen, Fujian Province, China

The final, formatted version of the article will be published soon.

    Objective: We aimed to investigate the clinical features of children with plastic bronchitis caused by pneumonia, and assess the risk factors for pleural effusion (PE) in plastic bronchitis. Methods: A retrospective study was conducted on children with plastic bronchitis and hospitalized in Xiamen Children's Hospital from January 2017 to April 2023. Participants were categorized based on the presence of PE. Their clinical manifestations and laboratory findings were analyzed. Results: Sixty-nine children with plastic bronchitis were enrolled: 34 cases (49.27%) in the non-PE group and 35 cases (50.72%) in the PE group. No significant differences were found in sex, age, and etiology between the two groups. Significant differences were found in fever duration, C-reactive protein (CRP), albumin and lactate dehydrogenase (LDH) (p < 0.05). A receiver operating characteristic (ROC) curve analysis showed that the cut-off values for higher risk of PE were CRP > 31.66 mg/L or LDH > 551 U/L. The prediction of PE was performed with the combination of CRP > 31.66 mg/L and LDH > 551 U/L, using multivariate logistic regression analysis. The area under the curve (AUC) for logistic regression was 0.797. Elevated CRP increased the risk of PE (odds ratio [OR] 8.358, 95% confidence interval [CI] 2.179-42.900, p = 0.0042), elevated LDH increased the risk of PE (OR 5.851 [95% CI 1.950-19.350], p = 0.0023). Conclusion: The combined detection of CRP and LDH helps predict the risk of PE in children with plastic bronchitis caused by pneumonia.

    Keywords: Plastic bronchitis, Pleural Effusion, Clinical Characteristics, Risk factors, Children, Inflammation

    Received: 05 Apr 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Lin, Xu, Zhang, Zhu and Zhuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Enhui Xu, Xiamen Children's Hospital, Xiamen, China
    Tan Zhang, Xiamen Children's Hospital, Xiamen, China
    Deyi Zhuang, Xiamen Children's Hospital, Xiamen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.