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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Hematology and Hematological Malignancies
Volume 12 - 2024 | doi: 10.3389/fped.2024.1408231

High NT pro-BNP levels in children with malignant disorder receiving intensive fluid treatment: a prospective comparative study

Provisionally accepted
Weronika Pawlik Weronika Pawlik 1*Joanna Strzemecka Joanna Strzemecka 1Albert Stachura Albert Stachura 2Aleksandra Królak Aleksandra Królak 1Tomasz Ociepa Tomasz Ociepa 1
  • 1 Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland
  • 2 Department of Methodology, Medical University of Warsaw, Warsaw, Poland

The final, formatted version of the article will be published soon.

    Hematologic malignancies are a well-known risk factor for cardiovascular disease development. Chemotherapeutic protocols commonly include intensive fluid therapy (IFT), which may negatively influence the cardiovascular system and predispose to arterial hypertension. This study aims to evaluate atrial natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and changes in blood pressure in children with hematological malignancies undergoing intensive fluid therapy. This prospective cohort study comprised thirteen children. 24-hour ambulatory blood pressure monitoring (ABPM) and concentrations of NT-proBNP and hs-TnT were performed on the first day of IFT and during follow-up. There were no statistically significant differences in 24-hour, daytime, night-time systolic (SBP) and diastolic blood pressure (DBP), SBP and DBP dipping, and the number of nondippers during intensive fluid therapy compared to the control points. The mean NT-proBNP concentration at 24 hour was 321.27 ± 318.08 pg/ml and was significantly higher compared with baseline (79.13 ± 105.42 pg/ml) and follow-up (175.92 ± 241.48 pg/ml); p values 0.005 and p=0.006 respectively. Troponin T concentration at 24 hour was not significantly different compared with baseline and follow-up. These results show no significant influence of intensive fluid therapy on blood pressure profile. In contrast, an increase in NT-proBNP values 24 hours after the start of fluid therapy may reflect the impact of fluid overload on the cardiovascular system.

    Keywords: ambulatory blood pressure monitoring1, children2, hematological malignancies3, intensive fluid therapy4, cardiac biomarkers5, atrial natriuretic peptide (NT-proBNP)6, highsensitivity troponin T (hs-TnT)7

    Received: 27 Mar 2024; Accepted: 01 Nov 2024.

    Copyright: © 2024 Pawlik, Strzemecka, Stachura, Królak and Ociepa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Weronika Pawlik, Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, Szczecin, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.