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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Neonatology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1404196
This article is part of the Research Topic What is new on the Horizon in Neonatology? Recent Advances in Monitoring, Diagnostics, and Therapeutics in Neonatal Care. View all 12 articles

The Association between Serum 25-Hydroxyvitamin D Levels and Retinopathy of Prematurity in Preterm Infants

Provisionally accepted
Yin Xiangyun Yin Xiangyun 1Xu Shimin Xu Shimin 2Zhang Xuefei Zhang Xuefei 3Li Liangliang Li Liangliang 1Xi Hongmin Xi Hongmin 1Ma Lili Ma Lili 1Sun Mengya Sun Mengya 1Yang Ping Yang Ping 1Li Xianghong Li Xianghong 1*Hong Jiang Hong Jiang 1*
  • 1 The Affiliated Hospital of Qingdao University, Qingdao, China
  • 2 Beijing Jingdu Children's Hospital, Bejing, China
  • 3 Qingdao University, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    Objective: This study aimed to investigate the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and retinopathy of prematurity (ROP) in premature infants one month after birth.Preterm infants (gestational age <32 weeks) admitted to the Affiliated Hospital of Qingdao University from 2017 to 2022 were divided into ROP and non-ROP groups based on ROP occurrence any stage. Serum 25(OH)D levels and clinical data were compared between the two groups at 1 month after birth, and the relationship between vitamin D levels and ROP was analyzed.Results: Among the 217 premature infants included, 55 (25.35%) were in the ROP group, and 162 (74.65%) were in the non-ROP group. The ROP group had lower gestational age and birth weight, longer invasive ventilation (IV), non-invasive ventilation (NIV), and oxygen therapy times compared to the non-ROP group. Apgar scores, cesarean delivery, and antenatal steroids ratios were lower in the ROP group, while sepsis and pulmonary surfactant utilization ratios were higher (all p< 0.05). Significant differences in serum 25-(OH)D levels were observed among children in the non-ROP group (14.20 ± 5.07ng/ml) , ROP treated group (7.891 ± 1.878ng/ml) , and untreated group(12.168 ± 4.354ng/ml) (p < 0.001).Multivariate regression analysis identified antenatal steroids as protective factors and lower birth weight, serum 25-(OH)D levels , long-term invasive mechanical ventilation, and sepsis as independent risk factors for ROP in premature infants. Conclusion:Vitamin D, lower birth weight, long-term invasive mechanical ventilation, and sepsis were associated with incidence of ROP in preterm infants. Vitamin D was associated with the severity of ROP, emphasizing the importance of prudent vitamin D supplementation and regular monitoring of serum 25-(OH)D levels.

    Keywords: Retinopathy of Prematurity, Serum 25-hydroxyvitamin D, lower birth weight infants, preterm infant, Sepsis

    Received: 20 Mar 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Xiangyun, Shimin, Xuefei, Liangliang, Hongmin, Lili, Mengya, Ping, Xianghong and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Li Xianghong, The Affiliated Hospital of Qingdao University, Qingdao, China
    Hong Jiang, The Affiliated Hospital of Qingdao University, Qingdao, China

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