HongXing Lin
Pingxiang Luo
*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Neonatology
Volume 12 - 2024 |
doi: 10.3389/fped.2024.1392308
Risk of low levels of blood group antibodies mediating hemolysis in ABO-incompatible neonates with negative three hemolysis tests
Provisionally accepted- Fujian Maternity and Child Health Hospital, Fuzhou, China
Objective: To explore the risk of low-level blood group antibody-mediated hemolysis in ABO-incompatible newborns with negative three hemolysis tests, aiming to assist in the identification and management of neonatal jaundice.A retrospective case-control study was performed in 892 children with jaundice.The patients were divided into three groups: group I, ABO compatible, negative three hemolysis tests; group II, ABO incompatible, negative three hemolysis tests; and group III, ABO incompatible, positive three hemolysis tests. We analyzed the differences in clinical data, blood routine and biochemical laboratory results.Results: 1) Patients in group II had higher levels of mean corpuscular volume (MCV), standard deviation of red blood cell volume distribution width (RDW-SD), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and bile acid (BA) than those in group I (P < 0.05). However, there were no statistically significant differences in the MCV, ALT, ALP and BA levels between groups II and III (P > 0.05). 2) Mean corpuscular hemoglobin concentration (MCHC) > 359.5g/L, cell volume distribution width (RDW-CV) > 15.95%, and reticulocyte count (RET) > 4.235% were identified as independent predictors of positive hemolysis test results (P<0.001). The combination of MCHC, RDW-CV, and RET% yielded an AUC of 0.841.Low-level blood group antibody-mediated hemolysis may occur in ABO-incompatible neonates even when three hemolysis tests are negative. Changes in liver function parameters must be monitored. The combination of MCHC, RDW-CV, and RET% can be used to improve the detection rate of HDN. Keywords: ABO hemolytic disease of the newborn, blood group antibodies, three hemolysis tests, mean corpuscular hemoglobin concentration, coefficient of variation of red blood cell volume distribution width, reticulocyte percentage
Keywords: ABO hemolytic disease of the newborn, Blood group antibodies, hree hemolysis tests, Mean corpuscular hemoglobin concentration, coefficient of variation of red blood cell volume distribution width
Received: 27 Feb 2024; Accepted: 19 Jul 2024.
Copyright: © 2024 Lin, Luo, Liu, Lin, Que and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Pingxiang Luo, Fujian Maternity and Child Health Hospital, Fuzhou, China
Chen Liu, Fujian Maternity and Child Health Hospital, Fuzhou, China
Xiaosong Lin, Fujian Maternity and Child Health Hospital, Fuzhou, China
Chengwen Que, Fujian Maternity and Child Health Hospital, Fuzhou, China
Wenhui Zhong, Fujian Maternity and Child Health Hospital, Fuzhou, China
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