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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Endocrinology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1388437

Case report: Plummer's adenoma in Prader-Willi Syndrome

Provisionally accepted
Domenico Corica Domenico Corica 1Fabio Toscano Fabio Toscano 1Mariacarla Moleti Mariacarla Moleti 2Giorgia Pepe Giorgia Pepe 1Alfredo Campenni Alfredo Campenni 3Guido Fadda Guido Fadda 1Gianlorenzo Dionigi Gianlorenzo Dionigi 4Carmelo Romeo Carmelo Romeo 1Tommaso Aversa Tommaso Aversa 1Malgorzata G. Wasniewska Malgorzata G. Wasniewska 1*
  • 1 Department of Human Pathology in Adulthood and Childhood Gaetano Barresi, University of Messina, Messina, Italy
  • 2 Division of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
  • 3 Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy
  • 4 Immunorheumatology Research Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy

The final, formatted version of the article will be published soon.

    Thyroid nodules in children are less common than in adult but they are about two-to three-fold at risk of being malignant compared to adults. Among thyroid nodular diseases, Plummer's adenoma is a very rare occurrence in pediatrics and nowadays there is no literature evidence of this diagnosis in patients with Prader-Willi Syndrome (PWS). We report a case of a 9-year-old caucasian boy affected by PWS presented with a rapidly growing palpable mass in the thyroid lodge associated with subclinical hyperthyroidism. Laboratory and further examinations (thyroid ultrasound, fine needle aspiration of the nodule, scintigraphy) were strongly suggestive for Plummer’s adenoma, so the patient underwent left hemi-thyroidectomy surgery and the anatomo-pathological examination confirmed the diagnosis. Our case describes the first evidence of isolated follicular adenoma in children with PWS. Surgery is the only therapeutic option in younger children. Further evidences are necessary to asses a possible correlation between these two conditions and the existence of potential risk factors

    Keywords: Plummer's Adenoma, Subclinical hyperthyroidism, Children, Thyroid Nodule, gh therapy

    Received: 28 Feb 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Corica, Toscano, Moleti, Pepe, Campenni, Fadda, Dionigi, Romeo, Aversa and Wasniewska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Malgorzata G. Wasniewska, Department of Human Pathology in Adulthood and Childhood Gaetano Barresi, University of Messina, Messina, Italy

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