AUTHOR=Chang Lung , Huang Ching-Ying , Chiu Nan-Chang , Wang Jin-Yuan , Chi Hsin , Huang Tsung-Ning Daniel 

TITLE=Effectiveness of pre-Omicron COVID-19 mRNA vaccines against hospitalizations in infection-naïve children: a case-control study

JOURNAL=Frontiers in Pediatrics

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1387086

DOI=10.3389/fped.2024.1387086

ISSN=2296-2360

ABSTRACT=<p>This case–control study spanned from July 2022 to September 2023, focusing on the pre-Omicron COVID-19 mRNA vaccine effectiveness against the Omicron variant in children without prior SARS-CoV-2 exposure. We reported that pre-Omicron COVID-19 mRNA vaccines significantly reduced Omicron-induced hospitalizations in infection-naïve Taiwanese children. Our study also highlighted the socioeconomic factors influencing COVID-19 vulnerability among the children population.</p>