The final, formatted version of the article will be published soon.
PERSPECTIVE article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 12 - 2024 |
doi: 10.3389/fped.2024.1386082
Confronting the Challenge: A Regional Perspective by the Latin American Pediatric Infectious Diseases Society (SLIPE) Expert Group on Respiratory Syncytial Virus -Tackling the Burden of Disease and Implementing Preventive Solutions
Provisionally accepted
Roberto Debbag
1*
María L. Ávila-Agüero
2,3
José Brea
4
Helena Brenes-Chacon
2
Manuel Colomé
5*
Rodrigo De Antonio
6
Alejandro Díaz-Díaz
7
Luiza H. Falleiros-Arlant
8
Gerardo Fernández
9*
Angela Gentile
10
Iván F. Gutiérrez
11
Daniel Jarovsky
12
María d. Juárez
10*
Eduardo López-Medina
13
Abiel Mascareñas
14
Sebastián Ospina-Henao
15*
Marco A. Safadi
16
Xavier Sáez-Llorens
17*
Alejandra Soriano-Fallas
18*
Juan P. Torres
19
Carlos N. Torres-Martínez
20
Claudia Beltrán-Arroyave
21- 1 Vice-president of the Latin-American Vaccinology Society, Buenos Aires, Argentina
- 2 Pediatric Infectious Diseases Division, Hospital Nacional de Ninos Dr. Carlos Saenz Herrera. Caja Costarricense del Seguro Social (CCSS), San Jose, Costa Rica
- 3 Affiliated Researcher, Center for Infectious Disease Modeling and Analysis (CIDMA), Yale University, New Haven, Connecticut, United States
- 4 Professor of the Facultad de Ciencias de La salud del Instituto Tecnológico de Santo Domingo, Santo Domingo, Dominican Republic
- 5 Head epidemiologist at Hospital Pediátrico Dr. Hugo Mendoza, Santo Domingo, Dominican Republic
- 6 Director of the Centro de Vacunación e Investigación (CEVAXIN), Panama City, Panama
- 7 Pediatric Infectious Diseases Specialist at Hospital Pablo Tobón Uribe and Hospital General de Medellín, Medellin, Colombia
- 8 Coordinator of the Departamento de Salud del Niño de la Facultad de Medicina de la Universidad Metropolitana de Santos, São Paulo, Brazil
- 9 Pediatrician at the Department of Pediatrics and Infantil Surgery Oriente, Hospital Luis Calvo Mackenna and professor at the Faculty of Medicine, Universidad de Chile, Santiago, Chile
- 10 Epidemiology Department, Hospital de Niños R. Gutiérrez, Universidad de Buenos Aires, Buenos Aires, Argentina
- 11 Pediatric Infectious Diseases Specialist at Clínica Infantil Santa María del Lago, Bogota, Colombia
- 12 Pediatric Infectious Diseases Specialist and professor at the Faculdade de Ciências Médicas da Santa Casa de São Paulo. Secretary of the Immunization Department at the Pediatric Society at São Paulo, São Paulo, Brazil
- 13 Centro de Estudios en Infectología Pediátrica CEIP, Department of Pediatrics, Universidad del Valle. Clínica Imbanaco, and Grupo Quironsalud, Cali, Colombia
- 14 Department of Pediatric Infectious Diseases, Hospital Universitario “José E. Gonzalez”, Universidad Autónoma De Nuevo León, Nuevo Leon, Mexico
- 15 Faculty of Medicine, Universidad de Ciencias Médicas, UCIMED, San Jose, Costa Rica
- 16 Department of Pediatrics, Faculda de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil
- 17 Head of Infectious Diseases and Director of Clinical Research, Hospital del Niño Dr. José Renán Esquivel and Clinical Investigator of Senacyt (SNI) y Cevaxin, Panama city, Panama
- 18 Pediatric Infectious Diseases Division, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, Caja Costarricense de Seguro Social (CCSS), San Jose, Costa Rica
- 19 Department of Pediatrics and Child Surgery, Faculty of Medicine, University of Chile, Providencia, Chile
- 20 Assistant Professor Department of Pediatrics, Universidad El Bosque, Cafettor Médica SAS., Bogota, Colombia
- 21 Pediatric Infectious Diseases Specialist at Clínica El Rosario and Clínica del Prado. Faculty of Medicine, Universidad de Antioquia, Medellin, Colombia
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in children around the world. The post-pandemic era has resulted in a notable increase in reported cases of RSV infections, co-circulation of other respiratory viruses, shifts in epidemiology, altered respiratory season timing, and increased healthcare demand. Low-and middle-income countries are responsible for the highest burden of RSV disease, contributing significantly to health expenses during respiratory seasons and RSV-associated mortality in children. Until recently, supportive measures were the only intervention to treat or prevent RSV-infection, since preventive strategies like palivizumab are limited for high-risk populations. Advances in new available strategies, such as long-acting monoclonal antibodies during the neonatal period and vaccination of pregnant women, are now a reality. As the Regional Expert Group of the Latin American Pediatric Infectious Diseases Society (SLIPE), we sought to evaluate the burden of RSV infection in Latin America and the Caribbean (LAC) region, analyze current strategies to prevent RSV infection in children, and provide recommendations for implementing new strategies for preventing RSV infection in children in LAC region.
Keywords: respiratory syncytial virus, long-acting monoclonal antibodies, nirsevimab, Maternal vaccination, maternal RSV pre-F vaccination
Received: 14 Feb 2024; Accepted: 17 Jul 2024.
Copyright: © 2024 Debbag, Ávila-Agüero, Brea, Brenes-Chacon, Colomé, De Antonio, Díaz-Díaz, Falleiros-Arlant, Fernández, Gentile, Gutiérrez, Jarovsky, Juárez, López-Medina, Mascareñas, Ospina-Henao, Safadi, Sáez-Llorens, Soriano-Fallas, Torres, Torres-Martínez and Beltrán-Arroyave. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Roberto Debbag, Vice-president of the Latin-American Vaccinology Society, Buenos Aires, Argentina
Manuel Colomé, Head epidemiologist at Hospital Pediátrico Dr. Hugo Mendoza, Santo Domingo, Dominican Republic
Gerardo Fernández, Pediatrician at the Department of Pediatrics and Infantil Surgery Oriente, Hospital Luis Calvo Mackenna and professor at the Faculty of Medicine, Universidad de Chile, Santiago, Chile
María d. Juárez, Epidemiology Department, Hospital de Niños R. Gutiérrez, Universidad de Buenos Aires, Buenos Aires, Argentina
Sebastián Ospina-Henao, Faculty of Medicine, Universidad de Ciencias Médicas, UCIMED, San Jose, Costa Rica
Xavier Sáez-Llorens, Head of Infectious Diseases and Director of Clinical Research, Hospital del Niño Dr. José Renán Esquivel and Clinical Investigator of Senacyt (SNI) y Cevaxin, Panama city, Panama
Alejandra Soriano-Fallas, Pediatric Infectious Diseases Division, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, Caja Costarricense de Seguro Social (CCSS), San Jose, Costa Rica
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.