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CASE REPORT article

Front. Pediatr.
Sec. Pediatric Immunology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1381493

Fever, convulsions, and rash: A case report of neonatal lupus erythematosus with macrophage activation syndrome

Provisionally accepted
Jing Yu Jing Yu 1Guohui Xue Guohui Xue 2Liu Xiaohui Liu Xiaohui 1Chunlei Zhan Chunlei Zhan 1Jinshi Huang Jinshi Huang 1*
  • 1 Jiangxi Provincial Children's Hospital, Nanchang, China
  • 2 Jiujiang First People's Hospital, Jiujiang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Neonatal lupus erythematosus (NLE) is a rare acquired autoimmune disease associated with the entry of maternal antibodies into the fetal circulation via the placenta during pregnancy. Macrophage activation syndrome (MAS) is a severe hyperinflammatory disease. Herein, we present a case of NLE with MAS accompanied by fever, convulsions, and rash. High-dose gamma globulin and non-shock doses of steroids can be used as a first-line treatment for NLE with MAS. Fever can be a clinical manifestation of NLE, especially cutaneous lupus. Rash recession could be used to judge whether the disease is effectively controlled by treatment.

    Keywords: Neonatal lupus, Fever, Rash, Macrophage Activation Syndrome, Treatment

    Received: 03 Feb 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Yu, Xue, Xiaohui, Zhan and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jinshi Huang, Jiangxi Provincial Children's Hospital, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.