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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Cardiology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1380582
This article is part of the Research Topic Neonatal Cardiology and Cardiac Surgery in Congenital Heart Disease. View all 8 articles

Impact of postoperative necrotizing enterocolitis after neonatal cardiac surgery on neurodevelopmental outcome at one year of age

Provisionally accepted
Walter Knirsch Walter Knirsch 1*Alexandra A. De Silvestro Alexandra A. De Silvestro 1Verena Rathke Verena Rathke 1Christelle L'Ebraly Christelle L'Ebraly 2,3Julia C. Natterer Julia C. Natterer 4Juliane Schneider Juliane Schneider 5Nicole Sekarski Nicole Sekarski 2Beatrice Latal Beatrice Latal 6Cristina Borradori Tolsa Cristina Borradori Tolsa 7Maya S. Bouhabib Maya S. Bouhabib 8Katharina Fuhrer Kradolfer Katharina Fuhrer Kradolfer 9Martin Glöckler Martin Glöckler 10Marc R. Pfluger Marc R. Pfluger 10Lena Kaiser Lena Kaiser 10Angelo Polito Angelo Polito 11Janet Fiona Kelly-Geyer Janet Fiona Kelly-Geyer 12Michael Von Rhein Michael Von Rhein 6Swiss ORCHID Swiss ORCHID 13
  • 1 Pediatric Cardiology, Pediatric Heart Center, Children’s Research Center, University of Zurich, University Children's Hospital Zurich, Zurich, Switzerland
  • 2 Pediatric Cardiology, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud, Switzerland
  • 3 Pediatric Cardiology, Woman-Child-Adolescent Department, University of Geneva, University Hospitals of Geneva, Geneva, Geneva, Switzerland
  • 4 Pediatric Intensive Care Unit, Woman-Mother-Child Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud, Switzerland
  • 5 Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud, Switzerland
  • 6 Child Development Center; Children’s Research Center, University of Zurich, University Children's Hospital Zurich, Zurich, Switzerland
  • 7 Development and Growth, Department of Pediatrics, Faculty of Medicine, University of Geneva, University Hospitals of Geneva, Geneva, Geneva, Switzerland
  • 8 Pediatric Cardiology, Woman-Child-Adolescent Department, Faculty of Medicine, University of Geneva, University Hospitals of Geneva, Geneva, Geneva, Switzerland
  • 9 Neuropediatrics, University of Bern, Bern, Bern, Switzerland
  • 10 Pediatric Cardiology, Center for Congenital Heart Disease, Department of Cardiology and Cardiac Surgery, University Children’s Hospital Bern, Bern, Bern, Switzerland
  • 11 University Hospitals of Geneva, Geneva, Geneva, Switzerland
  • 12 Neonatology and Pediatric Intensive Care, Children’s Research Center, University of Zurich, University Children's Hospital Zurich, Zurich, Switzerland
  • 13 Swiss ORCHID, Zurich, Switzerland

The final, formatted version of the article will be published soon.

    What is the impact of postoperative cardiogenic necrotizing enterocolitis (NEC) on neurodevelopmental (ND) outcome at one year of age? Key findings:Postoperative NEC is associated with a prolonged intensive care unit (ICU) length of stay (LOS) and the total duration of the hospitalization, constituting an additional risk factor for neurodevelopmental impairment in newborns with congenital heart disease.Postoperative NEC constitutes an additional risk of neurodevelopmental impairment in infants undergoing cardiac surgery and should be prevented with clinical alert strategies and management.

    Keywords: congenital heart disease, neurodevelopmental outcome, neonates, Cardiopulmonary bypass surgery, complications

    Received: 01 Feb 2024; Accepted: 02 Jul 2024.

    Copyright: © 2024 Knirsch, De Silvestro, Rathke, L'Ebraly, Natterer, Schneider, Sekarski, Latal, Borradori Tolsa, Bouhabib, Fuhrer Kradolfer, Glöckler, Pfluger, Kaiser, Polito, Kelly-Geyer, Von Rhein and ORCHID. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Walter Knirsch, Pediatric Cardiology, Pediatric Heart Center, Children’s Research Center, University of Zurich, University Children's Hospital Zurich, Zurich, 8032, Switzerland

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