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ORIGINAL RESEARCH article

Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1360227
This article is part of the Research Topic Pediatric Respiratory Critical Illness: Etiology, Diagnosis, and Treatment View all 6 articles

BREATHING PATTERNS DURING SLEEP AND THEIR RELATIONSHIP WITH FEV1 IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS RESIDING AT HIGH ALTITUDE

Provisionally accepted
Elida Duenas-Meza Elida Duenas-Meza 1,2,3,4*Sarah Pulido-Fentanes Sarah Pulido-Fentanes 1Maria Isabel Escamilla Gil Maria Isabel Escamilla Gil 1Diego Severiche-Bueno Diego Severiche-Bueno 5Jenny L. Jurado Jenny L. Jurado 1Miguel R. Suarez Miguel R. Suarez 1Maria A. Bazurto-Zapata Maria A. Bazurto-Zapata 1NADIA J. PROAÑOS JURADO NADIA J. PROAÑOS JURADO 1,4Luis Giraldo-Cadavid Luis Giraldo-Cadavid 6
  • 1 Fundación Neumológica Colombiana, Bogotá, Colombia
  • 2 American Thoracic Society, New York, New York, United States
  • 3 Asociación Colombiana de Neurología, Bogotá, Cundinamarca, Colombia
  • 4 Universidad de La Sabana, Chía, Cundinamarca, Colombia
  • 5 Sleep Laboratory, Fundación Neumológica Colombiana, Bogotá, Cundinamarca, Colombia
  • 6 Universidad de La Sabana- Fundacion Neumologica Colombiana, Chía, Cundinamarca, Colombia

The final, formatted version of the article will be published soon.

    Introduction: Sleep-disordered breathing (SDB) and gas exchange disorders are common in patients with cystic fibrosis (CF). Currently, the impact of the disease on sleep patterns in patients living at high altitude and the relationship of these patterns to lung function are largely unknown. The aim of this study was to determine the frequency of SDB in children with CF aged 6 to 18 years and the relationship between SDB and lung function (FEV1).Methods: This is an analytical cross-sectional study of children aged 6-18 years diagnosed with CF. Spirometry before and after bronchodilators and polysomnography with capnography were performed. Descriptive analysis of qualitative and continuous variables was performed. Spearman's correlation coefficient was used to determine the correlation between polysomnogram and lung function (FEV1).Results: Twenty-four patients with CF were included. The mean age was 10.5 ± 3.1 years and 62.5% were male. Nine children had bronchiectasis on chest CT. The median absolute baseline FEV1 was 1,880 (1,355-2,325) mL and 98% (83-110%) of predicted value. No significant difference in FEV1% was observed between subjects with obstructive sleep apnea (OSA) and those without OSA (P=0.56). The prevalence of OSA was 66.7% in children younger than 13 years and 40% in children older than 13 years. The Spearman correlation coefficient between FEV1 and percentage of total sleep time with saturation less than 90% (T90) was rho -0.52 (p-value = 0.018), and between FEV1 and percentage of total sleep time with saturation less than 85% (T85) was statistically significant with rho -0.45 (p-value = 0.041). A positive correlation was observed between FEV1 and SpO2 during sleep with rho 0.53 and a statistically significant p-value(0.014).A high prevalence of sleep apnea was found in children with CF living at high altitude, with a negative correlation between FEV1 and T90 and T85 oxygenation indices, and a positive correlation between FEV1 and SpO2 during sleep.

    Keywords: Cystic Fibrosis, Sleep, high altitude, obstructive sleep apnea, Sleep disorder breathing (SDB)

    Received: 22 Dec 2023; Accepted: 28 Jun 2024.

    Copyright: © 2024 Duenas-Meza, Pulido-Fentanes, Escamilla Gil, Severiche-Bueno, Jurado, Suarez, Bazurto-Zapata, PROAÑOS JURADO and Giraldo-Cadavid. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Elida Duenas-Meza, Fundación Neumológica Colombiana, Bogotá, Colombia

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