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SYSTEMATIC REVIEW article

Front. Pediatr.
Sec. Pediatric Immunology
Volume 12 - 2024 | doi: 10.3389/fped.2024.1352879

Effects of probiotics on the prevention and treatment of children with allergic rhinitis: a meta-analysis of randomized controlled trials

Provisionally accepted
Huixia Liu Huixia Liu 1Yue Chen Yue Chen 1Huan Wang Huan Wang 1Xinyi Luo Xinyi Luo 2Dengpiao Xie Dengpiao Xie 1Qing Ji Qing Ji 3*Tian Li Tian Li 1
  • 1 Hospital of Chengdu University of Traditional Chinese Medicine, chengdu, China
  • 2 Chengdu Medical College, Chengdu, Sichuan, China
  • 3 Chengdu First People's Hospital, Chengdu, China

The final, formatted version of the article will be published soon.

    Recent studies have demonstrated the anti-allergic effects of probiotics in humans. However, their role in preventing and treating pediatric allergic rhinitis has not been thoroughly investigated. This study aimed to systematically review the efficacy and preventive effects of probiotics on pediatric allergic rhinitis.We systematically searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases for all relevant studies on probiotics and pediatric allergic rhinitis. Studies meeting the inclusion criteria were included, data were extracted, and metaanalyses were performed.Results: A total of 28 studies with 4765 participants were included in this study. The pooled resultsshowed that the use of probiotics was associated with a significant improvement in total nose symptom scores (SMD, -2.27; 95% CI, -3.26 to -1.29; P < 0.00001), itchy nose scores (SMD, -0.44; 95% CI, -0.80 to -0.07; P = 0.02), sneezing scores (SMD, -0.47; 95% CI, -0.84 to -0.10; P = 0.01), eye symptoms (SMD, -3.77; 95% CI, -5.47 to -2.07; P < 0.00001), and Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (SMD, -2.52; 95% CI, -4.12 to -0.92; P < 00001).However, the use of probiotics was not associated with the incidence of allergic rhinitis (RR, 0.9; 95% CI, 0.74-1.08; P = 0.26).The present study demonstrated that probiotics were effective and safe for improving pediatric allergic rhinitis symptoms and quality of life. However, probiotics could not prevent pediatric allergic rhinitis.

    Keywords: Meta-analysis, pediatric allergy rhinitis, Probiotics, prevention, Treatment

    Received: 14 Dec 2023; Accepted: 30 Jul 2024.

    Copyright: © 2024 Liu, Chen, Wang, Luo, Xie, Ji and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qing Ji, Chengdu First People's Hospital, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.