AUTHOR=Lindner Ole , Rotari Natalia , Yoshimi Ayami , Niemeyer Charlotte M. , Hettmer Simone 

TITLE=Case Report: Lomustine overdose in a 15-year-old, healthy adolescent—a prescription failure

JOURNAL=Frontiers in Pediatrics

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1339597

DOI=10.3389/fped.2024.1339597

ISSN=2296-2360

ABSTRACT=<p>Lomustine is an oral chemotherapy drug commonly used in pediatric neuro-oncology. We report on a 15-year-old formerly healthy boy, who was erroneously prescribed lomustine instead of an antibiotic for tonsillitis. He subsequently suffered from prolonged bone marrow aplasia with secondary fever in neutropenia and ubiquitous bleeding. Bone marrow regeneration started approximately 7 weeks after lomustine intake. No other permanent organ damage has been detected thus far. Oral chemotherapeutic drugs should only be prescribed by experts and dispensed in the smallest possible pack size.</p>