AUTHOR=Ye Hong , Nian Chunmiao , Zhou Lijun , Xie Yuman , Li Fan , Xue Tao , Han Xueping 

TITLE=A comparison of the time course of action and laryngeal mask airway insertion conditions with different doses of mivacurium for day-case urologic surgery in children: a prospective cohort study

JOURNAL=Frontiers in Pediatrics

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1330737

DOI=10.3389/fped.2024.1330737

ISSN=2296-2360

ABSTRACT=<sec><title>Objective</title><p>To investigate the time course of action of different doses of mivacurium and determine the appropriate dose for laryngeal mask airway (LMA) insertion for day-case urologic surgery in children.</p></sec><sec><title>Methods</title><p>A total of 105 patients who enrolled in this study between March 2021 and December 2021 were randomised into 3 groups: Group A (mivacurium 0.15 mg/kg, <italic>n</italic> = 35), Group B (mivacurium 0.20 mg/kg, <italic>n</italic> = 35) and Group C (mivacurium 0.25 mg/kg, <italic>n </italic>= 35). The different doses of mivacurium were injected before LMA insertion. The primary outcomes included the grading of conditions for the LMA insertion-18 score, onset time, recovery index and the duration that mivacurium was effective. Secondary outcomes included pulse oxygen saturation, mean blood pressure, heart rate and the incidence of adverse events.</p></sec><sec><title>Results</title><p>The score of the conditions for LMA insertion in Group A was significantly lower than in Groups C and B (<italic>p</italic> &lt; 0.005). There was a significant difference in the onset time between Groups B and A (<italic>p</italic> &lt; 0.005). There was no significant difference in the overall incidence of adverse reactions between these groups (<italic>p</italic> &gt; 0.05).</p></sec><sec><title>Conclusion</title><p>Anaesthesia with 0.2 mg/kg of mivacurium can effectively shorten the onset time and facilitate insertion of the LMA in children undergoing day-case urologic surgery.</p></sec>