AUTHOR=Hu Ke , He Su-Mei , Zhang Cun , Zhang Yi-Jia , Gu Qian , Shi Hao-Zhe , Wang Dong-Dong 

TITLE=Optimizing the initial tacrolimus dosage in Chinese children with lung transplantation within normal hematocrit levels

JOURNAL=Frontiers in Pediatrics

VOLUME=12

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1090455

DOI=10.3389/fped.2024.1090455

ISSN=2296-2360

ABSTRACT=<sec><title>Background</title><p>The appropriate initial dosage of tacrolimus is undefined in Chinese pediatric lung transplant patients with normal hematocrit values. The purpose of this study is to optimize the initial dose of tacrolimus in Chinese children who are undergoing lung transplantation and have normal hematocrit levels.</p></sec><sec><title>Methods</title><p>The present study is based on a published population pharmacokinetic model of tacrolimus in lung transplant patients and uses the Monte Carlo simulation to optimize the initial tacrolimus dosage in Chinese children with lung transplantation within normal hematocrit levels.</p></sec><sec><title>Results</title><p>Within normal hematocrit levels, for children with lung transplantation who do not carry the <italic>CYP3A5*1</italic> gene and have no coadministration with voriconazole, it is recommended to administer tacrolimus at a dosage of 0.02 mg/kg/day, divided into two doses, for children weighing 10–32 kg, and a dosage of 0.03 mg/kg/day, also divided into two doses, for children weighing 32–40 kg. For children with lung transplantation who carry the <italic>CYP3A5*1</italic> gene and have no coadministration with voriconazole, tacrolimus dosages of 0.02, 0.03, and 0.04 mg/kg/day split into two doses are recommended for children weighing 10–15, 15–32, and 32–40 kg, respectively. For children with lung transplantation who do not carry the <italic>CYP3A5*1</italic> gene and have coadministration with voriconazole, tacrolimus dosages of 0.01 and 0.02 mg/kg/day split into two doses are recommended for children weighing 10–17 and 17–40 kg, respectively. For children with lung transplantation who carry the <italic>CYP3A5*1</italic> gene and have coadministration with voriconazole, a tacrolimus dosage of 0.02 mg/kg/day split into two doses is recommended for children weighing 10–40 kg.</p></sec><sec><title>Conclusions</title><p>It is the first time to optimize the initial dosage of tacrolimus in Chinese children undergoing lung transplantation within normal hematocrit.</p></sec>