AUTHOR=Yeung Cindy Hoi Ting , Verstegen Ruud H. J. , Greenberg Rachel , Lewis Tamorah Rae 

TITLE=Pharmacokinetic and pharmacodynamic principles: unique considerations for optimal design of neonatal clinical trials

JOURNAL=Frontiers in Pediatrics

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1345969

DOI=10.3389/fped.2023.1345969

ISSN=2296-2360

ABSTRACT=<p>Core clinical pharmacology principles must be considered when designing and executing neonatal clinical trials. In this review, the authors discuss important aspects of drug dose selection, pharmacokinetics, pharmacogenetics and pharmacodynamics that stakeholders may consider when undertaking a neonatal or infant clinical trial.</p>