AUTHOR=Velasco Pablo , Bautista Francisco , Rubio Alba , Aguilar Yurena , Rives Susana , Dapena Jose L. , Pérez Antonio , Ramirez Manuel , Saiz-Ladera Cristina , Izquierdo Elisa , Escudero Adela , Camós Mireia , Vega-García Nerea , Ortega Margarita , Hidalgo-Gómez Gloria , Palacio Carlos , Menéndez Pablo , Bueno Clara , Montero Joan , Romecín Paola A. , Zazo Santiago , Alvarez Federico , Parras Juan , Ortega-Sabater Carmen , Chulián Salvador , Rosa María , Cirillo Davide , García Elena , García Jorge , Manzano-Muñoz Albert , Minguela Alfredo , Fuster Jose L. TITLE=The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP) JOURNAL=Frontiers in Pediatrics VOLUME=11 YEAR=2023 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1269560 DOI=10.3389/fped.2023.1269560 ISSN=2296-2360 ABSTRACT=

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. Therefore, several research and innovation studies are focusing on pediatric relapsed or refractory ALL (R/R ALL). Driven by this context and following the European strategic plan to implement precision medicine equitably, the Relapsed ALL Network (ReALLNet) was launched under the umbrella of SEHOP in 2021, aiming to connect bedside patient care with expert groups in R/R ALL in an interdisciplinary and multicentric network. To achieve this objective, a board consisting of experts in diagnosis, management, preclinical research, and clinical trials has been established. The requirements of treatment centers have been evaluated, and the available oncogenomic and functional study resources have been assessed and organized. A shipping platform has been developed to process samples requiring study derivation, and an integrated diagnostic committee has been established to report results. These biological data, as well as patient outcomes, are collected in a national registry. Additionally, samples from all patients are stored in a biobank. This comprehensive repository of data and samples is expected to foster an environment where preclinical researchers and data scientists can seek to meet the complex needs of this challenging population. This proof of concept aims to demonstrate that a network-based organization, such as that embodied by ReALLNet, provides the ideal niche for the equitable and efficient implementation of “what's next” in the management of children with R/R ALL.