AUTHOR=Räisänen Laura , Viljakainen Heli , Kolho Kaija-Leena 

TITLE=Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases

JOURNAL=Frontiers in Pediatrics

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1157547

DOI=10.3389/fped.2023.1157547

ISSN=2296-2360

ABSTRACT=<p>Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.</p>