AUTHOR=Huang Shuangshuang , Wang Hao , Zheng Huiwen , Li Wei , Shi Jianrong , Shen Chen , Tao Ran 

TITLE=Association between IL-6 polymorphisms and Atopic Dermatitis in Chinese Han children

JOURNAL=Frontiers in Pediatrics

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1156659

DOI=10.3389/fped.2023.1156659

ISSN=2296-2360

ABSTRACT=<sec><title>Introduction</title><p>Atopic Dermatitis (AD) is a chronic inflammatory skin disease that affects almost 20% of children and 2 -10% of adults worldwide. Previous studies revealed that Interleukin-6 (IL-6) plays an essential role in autoimmune and chronic inflammatory diseases. This study aims to investigate the associations between IL-6 polymorphisms and AD.</p></sec><sec><title>Methods</title><p>Blood samples were collected from 132 AD patients and 100 controls, and single nucleotide polymorphisms (SNPs) in IL-6 (rs2069840 (C/G), rs2066992 (G/T), rs2069837 (A/G) and rs1800796 (G/C)) were analyzed using Multiplex PCR-Based Next Generation Sequencing (NGS).</p></sec><sec><title>Results</title><p>Results showed that the A/G genotype of IL-6/rs2069837 was significantly associated with a 1.933-fold increased risk of AD compared to those patients with A/A genotype (OR 1.933; 95%CI 1.086-3.438; <italic>p</italic>=0.024). The combined A/G-G/G genotype raised AD risk by 1.856 times compared to patients with the A/A genotype in dominant model (OR: 1.856; 95% CI: 1.056-3.261; <italic>p</italic>=0.030). No association was observed for 3 other SNPs and 4 haplotypes.</p></sec><sec><title>Discussion</title><p>These findings suggested that the A/G genotype of IL-6/rs2069837 was more susceptible to AD than A/A genotype in Chinese Han children, indicating the risk role of IL-6/rs2069837 in the occurrence of AD.</p></sec>