AUTHOR=Shaki David , Hershkovitz Eli , Tamam Shai , Bollotin Arkadi , David Odeya , Yalovitsky Guy , Loewenthal Neta , Carmon Lior , Walker Dganit , Haim Alon 

TITLE=GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis

JOURNAL=Frontiers in Pediatrics

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1132296

DOI=10.3389/fped.2023.1132296

ISSN=2296-2360

ABSTRACT=<sec><title>Objective</title><p>To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS).</p></sec><sec><title>Design</title><p>Systematic review and mini meta-analysis of the literature.</p></sec><sec><title>Methods</title><p>A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis.</p></sec><sec><title>Results</title><p>In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients.</p></sec><sec><title>Conclusions</title><p>A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.</p></sec>