AUTHOR=Zhang Hua-yong , Xiao Min , Zhou Dan , Yan Fan , Zhang Yong 

TITLE=Platelet and ferritin as early predictive factors for the development of macrophage activation syndrome in children with Kawasaki disease: A retrospective case-control study

JOURNAL=Frontiers in Pediatrics

VOLUME=11

YEAR=2023

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1088525

DOI=10.3389/fped.2023.1088525

ISSN=2296-2360

ABSTRACT=<sec><title>Objective</title><p>To investigate the early predictive factors for Kawasaki disease complicated with macrophage activation syndrome (KD-MAS)</p></sec><sec><title>Methods</title><p>We performed a retrospective case-control study in children with KD from August 2017 to August 2022, involving 28 cases with KD-MAS and 112 cases not developing KD-MAS. Based on the univariate analysis, binary logistic regression was used to identify the early predictive factors for KD-MAS development, and the receiver operating characteristic curve (ROC) analysis was carried out to obtain the optimal cut-off value.</p></sec><sec><title>Results</title><p>Two predictive factors were associated with the development of KD-MAS, which were PLT (<italic>OR </italic>= 1.013, 95%<italic>CI</italic>, 1.001–1.026), and serum ferritin (<italic>OR </italic>= 0.991, 95%<italic>CI</italic>, 0.982–0.999). The cut-off value of PLT was 110 × 10<sup>9</sup>/L, and the cut-off value of serum ferritin was 548.4 ng/ml.</p></sec><sec><title>Conclusion</title><p>Children with KD who had a PLT count under 110 × 10<sup>9</sup>/L, and a serum ferritin level over 548.4 ng/ml are more likely to develop KD-MAS.</p></sec>