AUTHOR=Xiong Shiqiu , Jia Yang , Liu Chuanhe 

TITLE=IgE-expressing long-lived plasma cells in persistent sensitization

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.979012

DOI=10.3389/fped.2022.979012

ISSN=2296-2360

ABSTRACT=<p>Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE<sup>+</sup> long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE<sup>+</sup> LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE<sup>+</sup> PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE<sup>+</sup> LLPCs.</p>