AUTHOR=Zhou Ya Bin , Yao Jia Feng , Xu Zi Gang , Wu Rui Hui 

TITLE=Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.972224

DOI=10.3389/fped.2022.972224

ISSN=2296-2360

ABSTRACT=<p>Chronic neutrophilic leukemia (CNL) is a rare <italic>BCR-ABL</italic> negative myeloproliferative neoplasm that usually affects older adults with a poor prognosis. Leukemia cutis is an extramedullary manifestation of leukemia and may be misdiagnosed by dermatologists. Here, we describe a case of CNL in a 6-year-old Chinese girl with leukemia cutis as the first manifestation. Her skin rashes failed to attract the attention of dermatologists in early stages. The diagnosis was confirmed by peripheral smear, bone marrow studies, genomic analysis and skin biopsy.</p>