AUTHOR=Saito Mizuho , Nakazawa Tomoyuki , Toriumi Shun , Takasu Michihiko , Yagisawa Hiromi , Murano Yayoi , Miyazaki Nao , Kurahashi Hirokazu , Okumura Akihisa , Shimizu Toshiaki 

TITLE=Case report: Mild encephalitis with a reversible splenial lesion associated with SARS-CoV-2 infection in a patient with MYRF variant

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.971432

DOI=10.3389/fped.2022.971432

ISSN=2296-2360

ABSTRACT=<p>We report a 14-year-old girl with a heterozygous p. Gln403Arg variant in the <italic>MYRF</italic> gene, who had five episodes of encephalopathy. She experienced reduced consciousness, numbness in the arm, and impaired verbal communication from day 4 of SARS-CoV-2 infection. Magnetic resonance imaging of her head showed reduced water diffusion in the corpus callosum and deep white matter. These features were similar to those seen in her previous episodes of encephalopathy. She was treated with methylprednisolone pulse therapy and recovered completely within a week.</p>