AUTHOR=Mori Francesca , Saretta Francesca , Liotti Lucia , Giovannini Mattia , Castagnoli Riccardo , Arasi Stefania , Barni Simona , Mastrorilli Carla , Pecoraro Luca , Caminiti Lucia , Marseglia Gian Luigi , Barbaud Annick , Novembre Elio TITLE=Linear Immunoglobulin a Bullous Dermatosis in Children JOURNAL=Frontiers in Pediatrics VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.937528 DOI=10.3389/fped.2022.937528 ISSN=2296-2360 ABSTRACT=

Linear Immunoglobulin A Bullous Disease (LABD) is a rare dermatosis whose pathomechanisms are not yet completely understood. LABD has different features characterizing adults and children in terms of potential triggers, clinical manifestations, and prognosis. The aim of the present study is to review all neonatal and pediatric cases of LABD and summarize the major characteristics. Childhood LABD is mainly idiopathic with a benign prognosis. Neonatal cases are difficult to differentiate from infectious diseases and usually have a poor prognosis. Drugs are one of the possible triggers that can activate autoimmune responses through antigen mimicry and epitope spreading as well as different stimuli (e.g., infections, inflammatory diseases, trauma). The gold standard for the diagnosis is based on direct immunofluorescence. Prognosis is generally favorable but often depends on the prompt dermatological diagnosis, treatment and follow-up guaranteed by a multidisciplinary team, including pediatricians for this group of age.