AUTHOR=Olsen Braden , Bodea Jessica , Garcia Angela , Beebe Kristen , Campbell Courtney , Schwalbach Carly , Salzberg Dana , Miller Holly , Adams Roberta , Mirea Lucia , Castillo Paul , Horn Biljana , Bansal Sandhya , Mohanakumar Thalachallour , Ngwube Alexander 

TITLE=Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.913586

DOI=10.3389/fped.2022.913586

ISSN=2296-2360

ABSTRACT=<p>Vitamin D deficiency is prevalent in pediatric patients presenting for hematopoietic stem cell transplantation (HSCT) and has been linked to poor clinical outcomes. Using the data from a randomized control trial, in this paper we explore the effects of vitamin D supplementation on circulating cytokine levels during pediatric HSCT (<ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">www.clinicaltrials.gov</ext-link> as NCT03176849). A total of 41 children, 20 received Stoss therapy and 21 children received standard of care vitamin D supplementation. Levels of 25(OH)D and 20 cytokines were assessed at baseline and day +30. Significantly (<italic>P</italic> &lt; 0.05) higher levels of mostly proinflammatory cytokines, FGF, GCSF, TNFα, IL-2, IL-6, IP10 were detected pre-transplant for patients with low compared to those with normal vitamin D levels. In sex stratified models that compare changes in cytokines between Stoss vs. standard of care, females in the Stoss group show greater changes in mostly pro -inflammatory cytokines- IP-10 (<italic>P</italic> = 0.0047), MIG (<italic>P</italic> = 0.009), and RANTES (<italic>P</italic> = 0.0047), IL-2R (<italic>P</italic> = 0.07) and IL-6(<italic>P</italic> = 0.069). Despite a small sample size, these findings suggest vitamin D deficiency affects the pre-transplant cytokine milieu and higher doses of vitamin D (Stoss therapy) appears to influence proinflammatory cytokine responses in a sex specific manner during pediatric HSCT. Larger clinical trials are warranted to validate these results.</p>