AUTHOR=Lu Jinmiao , Zhang Xunjie , Xu Hong , Li Zhiping 

TITLE=Inspiration to mRNA-based COVID-19 vaccination: Serious adverse case reports with hepatitis B vaccine in real-world

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.888686

DOI=10.3389/fped.2022.888686

ISSN=2296-2360

ABSTRACT=<sec><title>Objectives</title><p>The hepatitis B vaccine comprises hepatitis B surface antigen (HBsAg) produced by transgenic yeast cells. There are few serious adverse events (SAE) reports after Hepatitis B vaccination.</p></sec><sec><title>Methods</title><p>The authors searched the Chinese legal documents database for all SAE with Hepatitis B vaccination from January 2010 to January 2022.</p></sec><sec><title>Results</title><p>All seven patients received yeast-derived recombinant hepatitis B vaccine. Three cases of myocarditis (death), 2 cases of interstitial pneumonia (death), and 2 cases of encephalitis. The mean time of onset of SAE was 8.3 ± 4.3 h after vaccination.</p></sec><sec><title>Conclusion</title><p>The mechanism of vaccine-induced myocarditis may come from immune protein reactions. Based on the experience of Hepatitis B vaccine adverse events, we present new insights into the mechanism of myocarditis caused by the COVID-19 vaccine.</p></sec>