AUTHOR=Cao Meng , Li Shu , Tang Yucheng , Zou Yu 

TITLE=A Meta-Analysis of High-Intensity Interval Training on Glycolipid Metabolism in Children With Metabolic Disorders

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.887852

DOI=10.3389/fped.2022.887852

ISSN=2296-2360

ABSTRACT=<sec><title>Objective</title><p>Metabolic disorders are common among children and adolescents with obesity and are associated with insulin resistance, hyperlipidemia, hypertension, and other cardiovascular risk factors. High-intensity interval training (HIIT) is a time-efficient method to improve cardiometabolic health. We performed a meta-analysis to determine the effects of HIIT on glycolipid metabolism in children with metabolic disorders.</p></sec><sec><title>Methods</title><p>Meta-analyses were conducted to determine the effect of HIIT on glycolipid metabolism markers. Subgroup analysis with potential moderators was explored [i.e., training intensity standard and work/rest time ratio (WRR)].</p></sec><sec><title>Results</title><p>Eighteen trials involving 538 participants were included. HIIT showed positive effects on glycolipid metabolism, such as triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), blood glucose (BG), blood insulin (BI), and homeostasis model assessment (HOMA)-IR, when compared to the non-training control group (CON); in addition to BG (<italic>p</italic> = 0.257), the combined results of other indicators have high heterogeneity (<italic>p</italic> = 0.000). HIIT showed no superior effects when compared to moderate-intensity training (MIT). Subgroup analysis demonstrated that HIIT protocol with a WRR of 1:1 was superior to MIT for reducing TG and LDL-C and used %maximal aerobic speed (MAS) as the exercise intensity was superior to MIT for reducing TG. HIIT protocol used %heart rate (HR) as the exercise intensity was superior to MIT for increasing HDL-C, decreasing BI, and HOMA-IR.</p></sec><sec><title>Conclusion</title><p>HIIT improved glycolipid metabolism in children with metabolic disorders. WRR and training intensity can affect the intervention effects of HIIT.</p></sec><sec><title>Systematic Review Registration</title><p>[<ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.crd.york.ac.uk/</ext-link>], identifier [CRD42021291473]</p></sec>