AUTHOR=Meng Qinghong , Wang Bingsong , Zhang Xianlai , Li Zhen , Wang Wenjie , Yao Kaihu 

TITLE=Case Report: Various Clinical Manifestations Caused by Varicella-Zoster Virus in a Family

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.876250

DOI=10.3389/fped.2022.876250

ISSN=2296-2360

ABSTRACT=<p>A family cluster of varicella-zoster virus (VZV) infections was reported. Four family members (two children and their parents) continuously develop varicella after the grandmother’s herpes zoster. The unvaccinated 16-month-old infant and his mother developed primary varicella with atypical clinical presentation; however, his 28-year-old father presented with a typical generalized vesicular rash. His vaccinated 4-year-old sister was clinically mild, which could be defined as a breakthrough varicella case. They infected the same virus strain but presented various clinical forms.</p>