AUTHOR=Zhou Bo , Xiong Wenyi , Bai Ke , Dang Hongxing , Li Jing , Xu Feng , Fu Yue-qiang , Liu Chengjun 

TITLE=Clinical Application Value of Pharmacokinetic Parameters of Vancomycin in Children Treated in the Pediatric Intensive Care Unit

JOURNAL=Frontiers in Pediatrics

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.867712

DOI=10.3389/fped.2022.867712

ISSN=2296-2360

ABSTRACT=<sec><title>Objective</title><p>To explore the efficacy and safety of vancomycin as measured by pharmacokinetic/pharmacodynamic parameters in children with severe infection in the Pediatric Intensive Care Unit (PICU) and to determine the appropriate threshold for avoiding nephrotoxicity.</p></sec><sec><title>Methods</title><p>The medical records of hospitalized children with severe infection treated with vancomycin in the PICU of a tertiary pediatric hospital from September 2018 to January 2021 were retrospectively collected. Univariate analysis was used to assess the correlation between vancomycin pharmacokinetic/pharmacodynamic parameters and therapeutic efficacy or vancomycin-related nephrotoxicity. Binary logistic regression was used to analyze the risk factors for vancomycin-related nephrotoxicity. The vancomycin area under the concentration-time curve over 24 h (AUC<sub>0–24</sub>) threshold was determined by receiver operating characteristic (ROC) curve analysis.</p></sec><sec><title>Results</title><p>One hundred and 10 patients were included in this study. Seventy-six patients (69.1%) exhibited clinically effective response, while the rest exhibited clinically ineffective response. There were no significant differences in APACHE II score, steady-state trough concentration, peak concentration or AUC<sub>0–24</sub> of vancomycin between the effective and ineffective groups. Among the 110 patients, vancomycin-related nephrotoxicity occurred in 15 patients (13.6%). Multivariate analysis showed that vancomycin treatment duration, trough concentration, and AUC<sub>0–24</sub> were risk factors for vancomycin-related nephrotoxicity. The ROC curve indicated that AUC<sub>0–24</sub> &lt; 537.18 mg.h/L was a suitable cutoff point for predicting vancomycin-related nephrotoxicity.</p></sec><sec><title>Conclusion</title><p>No significant correlations were found between the trough concentration or AUC<sub>0–24</sub> of vancomycin and therapeutic efficacy when the daily dose of vancomycin was approximately 40 mg/kg d, while the trough concentration and AUC<sub>0–24</sub> were both closely related to vancomycin-related nephrotoxicity. The combination of AUC<sub>0–24</sub> and trough concentration for therapeutic drug monitoring may reduce the risk of nephrotoxicity.</p></sec>